Microwave-enhanced transition metal-catalyzed decoration of 2(1H)-pyrazinone scaffolds

被引：50

作者：

Kaval, Nadya ^{[1
]}

Bisztray, Katalin ^{[1
]}

Dehaen, Wim ^{[1
]}

Kappe, C. Oliver ^{[2
]}

Van der Eycken, Erik ^{[1
]}

机构：

[1] Univ Leuven, Dept Chem, Organ Synth Lab, Louvain, Belgium

[2] Karl Franzens Univ Graz, Inst Chem, Graz, Austria

来源：

MOLECULAR DIVERSITY | 2003年 / 7卷 / 2-4期

关键词：

cyanation; dechlorination; Heck reaction; 2(1H)-pyrazinone; Sonogashira reaction; Stille reaction; Suzuki reaction;

D O I：

10.1023/B:MODI.0000006807.43408.d5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 2(1H)-pyrazinones have been demonstrated to be versatile building blocks for the synthesis of biologically active compounds. Here, an efficient method is described for the decoration of these interesting scaffolds. Microwave-assisted palladium catalyzed reactions allow the easy introduction of different substituents at the C3- and even at the rather unreactive C5-position of the pyrazinones. Stille, Suzuki, Heck, Sonogashira reactions, in addition to reductive dechlorinations, and cyanation reactions are investigated.

引用

页码：125 / 133

页数：9

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