Identification of novel genes coding for small expressed RNAs

被引：3833

作者：

Lagos-Quintana, M ^{[1
]}

Rauhut, R ^{[1
]}

Lendeckel, W ^{[1
]}

Tuschl, T ^{[1
]}

机构：

[1] Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37077 Gottingen, Germany

来源：

SCIENCE | 2001年 / 294卷 / 5543期

关键词：

D O I：

10.1126/science.1064921

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In Caenorhabditis elegans, lin-4 and let-7 encode 22- and 21-nucleotide (nt) RNAs, respectively, which function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as small temporal RNAs (stRNAs). We show that many 21- and 22-nt expressed RNAs, termed microRNAs, exist in invertebrates and vertebrates and that some of these novel RNAs, similar to let-7 stRNA, are highly conserved. This suggests that sequence-specific, posttranscriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.

引用

页码：853 / 858

页数：6

共 29 条

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