Comparison of safety and efficacy of convalescent plasma with fresh frozen plasma in severe covid-19 patients

被引：7

作者：

Bajpai, Meenu ^{[1
]}

Maheshwari, Ashish ^{[1
]}

Kumar, Suresh ^{[2
]}

Chhabra, Karan ^{[2
]}

Kale, Pratibha ^{[3
]}

Narayanan, Ashad ^{[4
]}

Gupta, Amita ^{[1
]}

Gupta, Ekta ^{[5
]}

Trehanpati, Nirupama ^{[5
]}

Agarwal, Reshu ^{[6
]}

Gupta, Kamini ^{[6
]}

Bhardwaj, Ankit ^{[7
]}

Islam, Mojahidul ^{[5
]}

Singh, Ravinder ^{[5
]}

Yadav, Pushpa ^{[5
]}

Kumar, Guresh ^{[8
]}

Sarin, Shiv K. ^{[4
]}

机构：

[1] Inst Liver & Biliary Sci, Dept Transfus Med, D1 Ilbs,D-1 Vast Kunj Rd, Delhi 110070, India

[2] Lok Nayak Jai Prakash Hosp, Dept Med, Maulana Azad Med Coll Campus, J6QP PRR,Jawaharlal Nehru Marg, Delhi 110002, India

[3] Inst Liver & Biliary Sci, Dept Microbiol, D1 Ilbs,D-1 Vast Kunj Rd, Delhi 110070, India

[4] Inst Liver & Biliary Sci, Dept Hepatol, D1 Ilbs,D-1,Vast Kunj Rd, Delhi 110070, India

[5] Inst Liver & Biliary Sci, Dept Mol & Cellular Med, D1 Ilbs,D-1 Vast Kunj Rd, Delhi 110070, India

[6] Inst Liver & Biliary Sci, Dept HepatoVirol, D1 Ilbs,D-1 Vast Kunj Rd, Delhi 110070, India

[7] Inst Liver & Biliary Sci, Dept Clin Res, D1 Ilbs,D-1 Vast Kunj Rd, Delhi 110070, India

[8] Inst Liver & Biliary Sci, Dept Res, D1 Ilbs,D-1 Vast Kunj Rd, Delhi 110070, India

来源：

ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS | 2022年 / 94卷 / 04期

关键词：

COVID-19; convalescent plasma; donor plasmapheresis; ARDS; immunoglobulins; antibodies;

D O I：

10.1590/0001-3765202220210202

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

background: Role of Convalescent plasma (COPLA) to treat severe COVID-19 is under investigation. We compared efficacy and safety of COPLA with fresh frozen plasma (FFP) in severe COVID-19 patients. Methods: One group received COPLA with standard medical care (n = 14), and another group received random donor FFP, as control with standard medical care (n = 15) in severe COVID-19 disease. Results: The proportion of patients free of ventilation at day seven were 78.5% in COPLA group, and 93.3 % in control group were not significant (p= 0.258). However, improved respiratory rate, O2 saturation, SOFA score, and Ct value were observed in the COPLA group. No serious adverse events were noticed by plasma transfusion in both groups.

引用

页数：8

共 18 条

[1]

Agarwal A., 2020, BMJ, V371, pM3939, DOI 10.1136/BMJ.M3939

[2]

Cao B, 2020, NEW ENGL J MED, V382, P1787, DOI [10.1056/NEJMoa2001282, 10.1056/NEJMc2008043]

[3] Convalescent plasma as a potential therapy for COVID-19 [J].

Chen, Long ;

Xiong, Jing ;

Bao, Lei ;

Shi, Yuan .

LANCET INFECTIOUS DISEASES, 2020, 20 (04) :398-400

[4] The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia [J].

Coelho Moraes de Brito, Rita de Cassia ;

Lucena-Silva, Norma ;

Torres, Leuridan Cavalcante ;

Luna, Carlos Feitosa ;

Correia, Jailson de Barros ;

Pontes da Silva, Giselia Alves .

BMC PULMONARY MEDICINE, 2016, 16

[5]

DRUGS AND COSMETICS ACT AND RULES, 1940, SECT XB XIIB

[6] Effectiveness of convalescent plasma therapy in severe COVID-19 patients [J].

Duan, Kai ;

Liu, Bende ;

Li, Cesheng ;

Zhang, Huajun ;

Yu, Ting ;

Qu, Jieming ;

Zhou, Min ;

Chen, Li ;

Meng, Shengli ;

Hu, Yong ;

Peng, Cheng ;

Yuan, Mingchao ;

Huang, Jinyan ;

Wang, Zejun ;

Yu, Jianhong ;

Gao, Xiaoxiao ;

Wang, Dan ;

Yu, Xiaoqi ;

Li, Li ;

Zhang, Jiayou ;

Wu, Xiao ;

Li, Bei ;

Xu, Yanping ;

Chen, Wei ;

Peng, Yan ;

Hu, Yeqin ;

Lin, Lianzhen ;

Liu, Xuefei ;

Huang, Shihe ;

Zhou, Zhijun ;

Zhang, Lianghao ;

Wang, Yue ;

Zhang, Zhi ;

Deng, Kun ;

Xia, Zhiwu ;

Gong, Qin ;

Zhang, Wei ;

Zheng, Xiaobei ;

Liu, Ying ;

Yang, Huichuan ;

Zhou, Dongbo ;

Yu, Ding ;

Hou, Jifeng ;

Shi, Zhengli ;

Chen, Saijuan ;

Chen, Zhu ;

Zhang, Xinxin ;

Yang, Xiaoming .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (17) :9490-9496

[7] Compassionate Use of Remdesivir for Patients with Severe Covid-19 [J].

Grein, J. ;

Ohmagari, N. ;

Shin, D. ;

Diaz, G. ;

Asperges, E. ;

Castagna, A. ;

Feldt, T. ;

Green, G. ;

Green, M. L. ;

Lescure, F-X ;

Nicastri, E. ;

Oda, R. ;

Yo, K. ;

Quiros-Roldan, E. ;

Studemeister, A. ;

Redinski, J. ;

Ahmed, S. ;

Bernett, J. ;

Chelliah, D. ;

Chen, D. ;

Chihara, S. ;

Cohen, S. H. ;

Cunningham, J. ;

Monforte, A. DArminio ;

Ismail, S. ;

Kato, H. ;

Lapadula, G. ;

L'Her, E. ;

Maeno, T. ;

Majumder, S. ;

Massari, M. ;

Mora-Rillo, M. ;

Mutoh, Y. ;

Nguyen, D. ;

Verweij, E. ;

Zoufaly, A. ;

Osinusi, A. O. ;

DeZure, A. ;

Zhao, Y. ;

Zhong, L. ;

Chokkalingam, A. ;

Elboudwarej, E. ;

Telep, L. ;

Timbs, L. ;

Henne, I ;

Sellers, S. ;

Cao, H. ;

Tan, S. K. ;

Winterbourne, L. ;

Desai, P. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (24) :2327-2336

[8]

Horby P, 2021, NEW ENGL J MED, V384, P693, DOI [10.1056/NEJMoa2022926, 10.1056/NEJMoa2021436]

[9] Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [J].

Huang, Chaolin ;

Wang, Yeming ;

Li, Xingwang ;

Ren, Lili ;

Zhao, Jianping ;

Hu, Yi ;

Zhang, Li ;

Fan, Guohui ;

Xu, Jiuyang ;

Gu, Xiaoying ;

Cheng, Zhenshun ;

Yu, Ting ;

Xia, Jiaan ;

Wei, Yuan ;

Wu, Wenjuan ;

Xie, Xuelei ;

Yin, Wen ;

Li, Hui ;

Liu, Min ;

Xiao, Yan ;

Gao, Hong ;

Guo, Li ;

Xie, Jungang ;

Wang, Guangfa ;

Jiang, Rongmeng ;

Gao, Zhancheng ;

Jin, Qi ;

Wang, Jianwei ;

Cao, Bin .

LANCET, 2020, 395 (10223) :497-506

[10] Safety Update: COVID-19 Convalescent Plasma in 20,000 Hospitalized Patients [J].

Joyner, Michael J. ;

Bruno, Katelyn A. ;

Klassen, Stephen A. ;

Kunze, Katie L. ;

Johnson, Patrick W. ;

Lesser, Elizabeth R. ;

Wiggins, Chad C. ;

Senefeld, Jonathon W. ;

Klompas, Allan M. ;

Hodge, David O. ;

Shepherd, John R. A. ;

Rea, Robert F. ;

Whelan, Emily R. ;

Clayburn, Andrew J. ;

Spiegel, Matthew R. ;

Baker, Sarah E. ;

Larson, Kathryn F. ;

Ripoll, Juan G. ;

Andersen, Kylie J. ;

Buras, Matthew R. ;

Vogt, Matthew N. P. ;

Herasevich, Vitaly ;

Dennis, Joshua J. ;

Regimbal, Riley J. ;

Bauer, Philippe R. ;

Blair, Janis E. ;

van Buskirk, Camille M. ;

Winters, Jeffrey L. ;

Stubbs, James R. ;

van Helmond, Noud ;

Butterfield, Brian P. ;

Sexton, Matthew A. ;

Soto, Juan C. Diaz ;

Paneth, Nigel S. ;

Verdun, Nicole C. ;

Marks, Peter ;

Casadevall, Arturo ;

Fairweather, DeLisa ;

Carter, Rickey E. ;

Wright, R. Scott .

MAYO CLINIC PROCEEDINGS, 2020, 95 (09) :1888-1897

← 1 2 →