Sharp Tuning of Head Direction and Angular Head Velocity Cells in the Somatosensory Cortex

被引：8

作者：

Long, Xiaoyang ^{[1
]}

Deng, Bin ^{[1
]}

Young, Calvin K. ^{[2
]}

Guo-Long Liu ^{[1
]}

Zhong, Zeqi ^{[1
]}

Chen, Qian ^{[3
]}

Yang, Hui ^{[1
]}

Sheng-Qing Lv ^{[1
]}

Chen, Zhe Sage ^{[4
]}

Sheng-jia Zhang ^{[1
]}

机构：

[1] Army Med Univ, Xinqiao Hosp, Dept Neurosurg, Chongqing 400037, Peoples R China

[2] Univ Otago, Brain Hlth Res Ctr, Dept Psychol, Dunedin 9054, New Zealand

[3] Army Med Univ, Coll Basic Med, Ctr Biomed Anal, Chongqing 400038, Peoples R China

[4] NYU, Sch Med, Dept Psychiat, Dept Neurosci & Physiol,Neurosci Inst, New York, NY 10016 USA

来源：

ADVANCED SCIENCE | 2022年 / 9卷 / 14期

基金：

中国国家自然科学基金;

关键词：

angular head velocity cells; fast-spiking neurons; head direction cells; somatosensory cortex; spatial cognitive maps; theta rhythmicity; FREELY MOVING RATS; SPEED CELLS; INHIBITORY INTERNEURONS; SPATIAL PERIODICITY; RESPONSE PROPERTIES; PATH-INTEGRATION; SILICON PROBES; MOTOR CORTEX; GRID CELLS; LAYER;

D O I：

10.1002/advs.202200020

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Head direction (HD) cells form a fundamental component in the brain's spatial navigation system and are intricately linked to spatial memory and cognition. Although HD cells have been shown to act as an internal neuronal compass in various cortical and subcortical regions, the neural substrate of HD cells is incompletely understood. It is reported that HD cells in the somatosensory cortex comprise regular-spiking (RS, putative excitatory) and fast-spiking (FS, putative inhibitory) neurons. Surprisingly, somatosensory FS HD cells fire in bursts and display much sharper head-directionality than RS HD cells. These FS HD cells are nonconjunctive, rarely theta rhythmic, sparsely connected and enriched in layer 5. Moreover, sharply tuned FS HD cells, in contrast with RS HD cells, maintain stable tuning in darkness; FS HD cells' coexistence with RS HD cells and angular head velocity (AHV) cells in a layer-specific fashion through the somatosensory cortex presents a previously unreported configuration of spatial representation in the neocortex. Together, these findings challenge the notion that FS interneurons are weakly tuned to sensory stimuli, and offer a local circuit organization relevant to the generation and transmission of HD signaling in the brain.

引用

页数：15

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