Molecular Mechanisms of Exercise and Healthspan

被引：24

作者：

Guan, Yuntian ^{[1
,2
]}

Yan, Zhen ^{[1
,2
,3
,4
]}

机构：

[1] Univ Virginia, Sch Med, Dept Pharmacol, Charlottesville, VA 22903 USA

[2] Univ Virginia, Ctr Skeletal Muscle Res, Robert M Berne Cardiovasc Res Ctr, Sch Med, Charlottesville, VA 22903 USA

[3] Univ Virginia, Sch Med, Dept Med, Charlottesville, VA 22903 USA

[4] Univ Virginia, Sch Med, Dept Mol Physiol & Biol Biophys, Charlottesville, VA 22903 USA

来源：

CELLS | 2022年 / 11卷 / 05期

关键词：

healthspan; exercise; chronic diseases; adaptations; ACTIVATED PROTEIN-KINASE; EXTRACELLULAR-SUPEROXIDE DISMUTASE; QUALITY-OF-LIFE; CHRONIC HEART-FAILURE; SKELETAL-MUSCLE HYPERTROPHY; MAXIMAL SHORTENING VELOCITY; LEFT-VENTRICULAR FUNCTION; BROWN ADIPOSE-TISSUE; ALL-CAUSE MORTALITY; GROWTH-FACTOR; 21;

D O I：

10.3390/cells11050872

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Healthspan is the period of our life without major debilitating diseases. In the modern world where unhealthy lifestyle choices and chronic diseases taper the healthspan, which lead to an enormous economic burden, finding ways to promote healthspan becomes a pressing goal of the scientific community. Exercise, one of humanity's most ancient and effective lifestyle interventions, appears to be at the center of the solution since it can both treat and prevent the occurrence of many chronic diseases. Here, we will review the current evidence and opinions about regular exercise promoting healthspan through enhancing the functionality of our organ systems and preventing diseases.

引用

页数：24

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