Identification of TAF1, HNF4A, and CALM2 as potential therapeutic target genes for liver fibrosis

被引：26

作者：

Ji, Dong ^{[1
]}

Chen, Guo-Feng ^{[1
]}

Wang, Jin-Cheng ^{[2
]}

Cao, Li-Hua ^{[3
]}

Lu, Fengmin ^{[4
]}

Mu, Xiao-Xin ^{[2
]}

Zhang, Xiao-Yu ^{[5
,6
]}

Lu, Xiao-Jie ^{[2
]}

机构：

[1] 302 Mil Hosp China, Liver Cirrhosis Treatment & Res Ctr 2, Beijing, Peoples R China

[2] Nanjing Med Univ, Affiliated Hosp 1, Liver Transplantat Ctr, Dept Gen Surg, Nanjing, Jiangsu, Peoples R China

[3] Third Hosp Qinhuangdao City, Liver Dis Ctr, Qinhuangdao, Hebei, Peoples R China

[4] Peking Univ, Hlth Sci Ctr, Dept Microbiol & Infect Dis Ctr, Beijing, Peoples R China

[5] Xuzhou Med Univ, Huaian Peoples Hosp 2, Dept Gen Surg, Div Gastrointestinal Surg, Huaian, Peoples R China

[6] Xuzhou Med Univ, Affiliated Huaian Hosp, Huaian, Peoples R China

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2019年 / 234卷 / 06期

关键词：

CALM2; hepatitis B virus; hepatitis C virus; HNF4A; liver fibrosis; TAF1; MOLECULAR INTERACTION DATABASE; ACTIVATION; EXPRESSION; TRANSCRIPTION; APOPTOSIS; VARIANTS;

D O I：

10.1002/jcp.27579

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The molecular mechanism of liver fibrosis caused by hepatitis C virus (HCV) is not clear. The aim of this study is to understand the molecular mechanism of liver fibrosis induced by HCV and to identify potential therapeutic targets for hepatic fibrosis. We analyzed gene expression patterns between high liver fibrosis and low liver fibrosis samples, and identified genes related to liver fibrosis. We identified TAF1, HNF4A, and CALM2 were related to the development of liver fibrosis. HNF4A is important for hepatic fibrogenesis, and upregulation of HNF4A is an ideal choice for treating liver fibrosis. The gene expression of CALM2 is significantly lower in liver fibrosis samples than nonfibrotic samples. TAF1 may serve as a biomarker for liver fibrosis. The results were further validated by an independent data set GSE84044. In summary, our study described changes in the gene expression during the occurrence and development of liver fibrosis. The TAF1, HNF4A, and CALM2 may serve as novel targets for the treatment of liver fibrosis.

引用

页码：9045 / 9051

页数：7

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