Identification of TAF1, HNF4A, and CALM2 as potential therapeutic target genes for liver fibrosis

被引：26

作者：

Ji, Dong ^{[1
]}

Chen, Guo-Feng ^{[1
]}

Wang, Jin-Cheng ^{[2
]}

Cao, Li-Hua ^{[3
]}

Lu, Fengmin ^{[4
]}

Mu, Xiao-Xin ^{[2
]}

Zhang, Xiao-Yu ^{[5
,6
]}

Lu, Xiao-Jie ^{[2
]}

机构：

[1] 302 Mil Hosp China, Liver Cirrhosis Treatment & Res Ctr 2, Beijing, Peoples R China

[2] Nanjing Med Univ, Affiliated Hosp 1, Liver Transplantat Ctr, Dept Gen Surg, Nanjing, Jiangsu, Peoples R China

[3] Third Hosp Qinhuangdao City, Liver Dis Ctr, Qinhuangdao, Hebei, Peoples R China

[4] Peking Univ, Hlth Sci Ctr, Dept Microbiol & Infect Dis Ctr, Beijing, Peoples R China

[5] Xuzhou Med Univ, Huaian Peoples Hosp 2, Dept Gen Surg, Div Gastrointestinal Surg, Huaian, Peoples R China

[6] Xuzhou Med Univ, Affiliated Huaian Hosp, Huaian, Peoples R China

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2019年 / 234卷 / 06期

关键词：

CALM2; hepatitis B virus; hepatitis C virus; HNF4A; liver fibrosis; TAF1; MOLECULAR INTERACTION DATABASE; ACTIVATION; EXPRESSION; TRANSCRIPTION; APOPTOSIS; VARIANTS;

D O I：

10.1002/jcp.27579

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The molecular mechanism of liver fibrosis caused by hepatitis C virus (HCV) is not clear. The aim of this study is to understand the molecular mechanism of liver fibrosis induced by HCV and to identify potential therapeutic targets for hepatic fibrosis. We analyzed gene expression patterns between high liver fibrosis and low liver fibrosis samples, and identified genes related to liver fibrosis. We identified TAF1, HNF4A, and CALM2 were related to the development of liver fibrosis. HNF4A is important for hepatic fibrogenesis, and upregulation of HNF4A is an ideal choice for treating liver fibrosis. The gene expression of CALM2 is significantly lower in liver fibrosis samples than nonfibrotic samples. TAF1 may serve as a biomarker for liver fibrosis. The results were further validated by an independent data set GSE84044. In summary, our study described changes in the gene expression during the occurrence and development of liver fibrosis. The TAF1, HNF4A, and CALM2 may serve as novel targets for the treatment of liver fibrosis.

引用

页码：9045 / 9051

页数：7

共 41 条

[1] Liver fibrosis [J].

Bataller, R ;

Brenner, DA .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (02) :209-218

[2] Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome-Associated Calmodulin Missense Variant, E141G [J].

Boczek, Nicole J. ;

Gomez-Hurtado, Nieves ;

Ye, Dan ;

Calvert, Melissa L. ;

Tester, David J. ;

Kryshtal, Dmytro O. ;

Hwang, Hyun Seok ;

Johnson, Christopher N. ;

Chazin, Walter J. ;

Loporcaro, Christina G. ;

Shah, Maully ;

Papez, Andrew L. ;

Lau, Yung R. ;

Kanter, Ronald ;

Knollmann, Bjoern C. ;

Ackerman, Michael J. .

CIRCULATION-CARDIOVASCULAR GENETICS, 2016, 9 (02) :136-146

[3] Activation of Slit2-Robo1 signaling promotes liver fibrosis [J].

Chang, Jianlan ;

Lan, Tian ;

Li, Changzheng ;

Ji, Xiaoqian ;

Zheng, Lingyun ;

Gou, Hongju ;

Ou, Yitao ;

Wu, Teng ;

Qi, Cuiling ;

Zhang, Qianqian ;

Li, Jiangchao ;

Gu, Quliang ;

Wen, Dingwen ;

Cao, Liu ;

Qiao, Liang ;

Ding, Yanqing ;

Wang, Lijing .

JOURNAL OF HEPATOLOGY, 2015, 63 (06) :1413-1420

[4] NEW CHALLENGES IN HEPATIC-FIBROSIS [J].

CLEMENT, B ;

LOREAL, O ;

LEVAVASSEUR, F ;

GUILLOUZO, A .

JOURNAL OF HEPATOLOGY, 1993, 18 (01) :1-4

[5] Reactome: a database of reactions, pathways and biological processes [J].

Croft, David ;

O'Kelly, Gavin ;

Wu, Guanming ;

Haw, Robin ;

Gillespie, Marc ;

Matthews, Lisa ;

Caudy, Michael ;

Garapati, Phani ;

Gopinath, Gopal ;

Jassal, Bijay ;

Jupe, Steven ;

Kalatskaya, Irina ;

Mahajan, Shahana ;

May, Bruce ;

Ndegwa, Nelson ;

Schmidt, Esther ;

Shamovsky, Veronica ;

Yung, Christina ;

Birney, Ewan ;

Hermjakob, Henning ;

D'Eustachio, Peter ;

Stein, Lincoln .

NUCLEIC ACIDS RESEARCH, 2011, 39 :D691-D697

[6] Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update [J].

Elpek, Gulsum Ozlem .

WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (23) :7260-7276

[7] Mesenchymal stem cell therapy for liver fibrosis [J].

Eom, Young Woo ;

Shim, Kwang Yong ;

Baik, Soon Koo .

KOREAN JOURNAL OF INTERNAL MEDICINE, 2015, 30 (05) :580-589

[8] Identification of novel targets for the diagnosis and treatment of liver fibrosis [J].

Fagone, Paolo ;

Mangano, Katia ;

Mammana, Santa ;

Pesce, Antonio ;

Pesce, Aurora ;

Caltabiano, Rosario ;

Giorlandino, Alexandra ;

Portale, Teresa Rosanna ;

Cavalli, Eugenio ;

Lombardo, Giuseppe A. G. ;

Coco, Marinella ;

Puleo, Stefano ;

Nicoletti, Ferdinando .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2015, 36 (03) :747-752

[9] Galectin-3 regulates myofibroblast activation and hepatic fibrosis [J].

Henderson, NC ;

Mackinnon, AC ;

Farnworth, SL ;

Poirier, F ;

Russo, FP ;

Iredale, JP ;

Haslett, C ;

Simpson, KJ ;

Sethi, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (13) :5060-5065

[10] Exploration, normalization, and summaries of high density oligonucleotide array probe level data [J].

Irizarry, RA ;

Hobbs, B ;

Collin, F ;

Beazer-Barclay, YD ;

Antonellis, KJ ;

Scherf, U ;

Speed, TP .

BIOSTATISTICS, 2003, 4 (02) :249-264

← 1 2 3 4 5 →