Molecular cloning and characterization of the alphaX subunit from CD11c/CD18 horse integrin

被引：6
|
作者：
Espino-Solis, Gerardo P. [1 ]
Osuna-Quintero, Joel [2 ]
Possani, Lourival D. [1 ]
机构：
[1] Univ Nacl Autonoma Mexico, Dept Med Mol & Bioproc, Inst Biotecnol, Cuernavaca 62210, Morelos, Mexico
[2] Univ Nacl Autonoma Mexico, Dept Ingn Celular & Biocatalisis, Inst Biotecnol, Cuernavaca 62210, Morelos, Mexico
来源：
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2008年 / 122卷 / 3-4期
关键词：
antibody; CD11c; dendritic cells; horse; I-domain; integrin;
D O I：
10.1016/j.vetimm.2007.12.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This work reports the cloning and sequence determination of the horse alpha subunit of the integrin CD11c/CD18, a marker of dendritic cells. A cDNA clone of 4582 base pairs was obtained. It encodes a protein segment of 1086 amino acid residues of the extracellular domain with 10 potential sites of glycosylation, a transmembrane domain of 32 residues and a C-terminal cytoplasmic tail of 24 residues. A phylogenetic analysis of this integrin shows close similarity (83%) with that of Canis familiaris. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：326 / 334
页数：9
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