Measles cases in highly vaccinated population of Novosibirsk, Russia, 2000-2005

被引：31

作者：

Atrasheuskaya, A. V. ^{[1
]}

Kulak, M. V. ^{[1
]}

Neverov, A. A. ^{[1
]}

Rubin, S. ^{[2
]}

Ignatyev, G. M. ^{[1
]}

机构：

[1] State Res Ctr Virol & Biotechnol Vector, Lab Immunol Safety, Koltsov 630559, Novosibirsk Reg, Russia

[2] US FDA, Ctr Biol Evaluat & Res, Bethesda, MD USA

来源：

VACCINE | 2008年 / 26卷 / 17期

关键词：

measles; Russia; genotyping; vaccine failure; neutralizing titers;

D O I：

10.1016/j.vaccine.2008.02.028

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

White the proportion of measles cases in vaccinees is expected to increase as vaccine coverage increases, such cases must be carefully investigated. The present study was conducted to examine possible contributions to vaccine failures (VFs) and to genetically characterize measles virus (MV) strains circulating in Novosibirsk, Russia during 2000-2005. Totally, 27 adult measles patients admitted to a regional hospital were prospectively enrolled in our study. Genetic characterization of the MV strains revealed circulation of genotypes A, D4 and D6 between 2000 and 2003 years; a genotype D6 MV was associated with the 2005 measles outbreak. Based on IgG avidity testing, half of the vaccinated patients demonstrated evidence of secondary vaccine failure (SVF). Patients, representing both levels of vaccine failure in our study were characterized by the tack of protective titers of neutralizing antibodies against circulating MVs, despite high IgG levels in many cases and high IgG avidity in SVF cases. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2111 / 2118

页数：8

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