A direct stereoselective approach to trans-2,3-disubstituted piperidines:: Application in the synthesis of 2-epi-CP-99,994 and (+)-epilupinine

被引：44

作者：

Ahari, M'hamed ^{[1
]}

Perez, Amandine ^{[1
]}

Menant, Christine ^{[1
]}

Vasse, Jean-Luc ^{[1
]}

Szymoniak, Jan ^{[1
]}

机构：

[1] Univ Reims, CNRS UMR 6229, Inst Chim Mol Reims, F-51687 Reims 2, France

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 12期

关键词：

D O I：

10.1021/ol800722a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple synthesis of enantiomerically pure piperidine esters is described, offering a straightforward access to the trans-2,3-disubstituted piperidine skeleton which is present in a broad range of biologically active compounds.

引用

页码：2473 / 2476

页数：4

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