Chronic perfluorooctanesulphonic acid (PFOS) exposure produces estrogenic effects in zebrafish

被引：80

作者：

Chen, Jiangfei ^{[1
]}

Wang, Xiaotong ^{[1
]}

Ge, Xiaoqing ^{[1
]}

Wang, Dingding ^{[1
]}

Wang, Ting ^{[1
]}

Zhang, Lingnan ^{[1
]}

Tanguay, Robert L. ^{[2
,3
]}

Simonich, Michael ^{[2
,3
]}

Huang, Changjiang ^{[1
]}

Dong, Qiaoxiang ^{[1
]}

机构：

[1] Wenzhou Med Univ, Inst Environm Safety & Human Hlth, Zhejiang Prov Key Lab Technol & Applicat Model Or, Wenzhou 325035, Peoples R China

[2] Oregon State Univ, Sinnhuber Aquat Res Lab, Environm & Mol Toxicol, Corvallis, OR 97333 USA

[3] Oregon State Univ, Environm Hlth Sci Ctr, Corvallis, OR 97333 USA

来源：

ENVIRONMENTAL POLLUTION | 2016年 / 218卷

基金：

中国国家自然科学基金;

关键词：

Zebrafish; PFOS; Sex hormone; Gonad; Estrogenic effects; PERFLUORINATED COMPOUNDS; SEX-DIFFERENTIATION; WATER; TOXICITY; FISH; PREGNANCY; CHEMICALS; SULFONATE; SEDIMENT; TISSUE;

D O I：

10.1016/j.envpol.2016.07.064

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Perfluorooctanesulphonic acid (PFOS) is a ubiquitous contaminant in the aquatic environment and our earlier studies demonstrated that chronic PFOS exposures lead to a female-biased sex ratio and decreased sperm quality in male zebrafish. The underlying mechanism for these reproductive effects is unknown. In the present study, 8 h post-fertilization (hpf) zebrafish were exposed to PFOS at 250 mu g/L for 5 months, and the levels of sex hormones, expression of sex determination related genes, and histological and ultrastructural changes of gonads were fully characterized. During the sex differentiation period, we observed elevated estradiol (E2) and decreased testosterone (T) levels in whole tissue homogenates from PFOS exposed juveniles. In fully mature adult male fish, serum E2 levels were slightly increased, however, the estrogen receptor alpha (esr1) was significantly elevated in PFOS treated male gonads. Histological and electron microscopic examinations revealed structural changes in the gonads of PFOS exposed male and female adult zebrafish. In summary, chronic PFOS exposure disrupts sex hormone level and related gene expression and impairs gonadal development, which may contribute to the previously reported PFOS reproductive toxicity. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：702 / 708

页数：7

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