Shuttle-Mediated Drug Delivery to the Brain

被引：69
|
作者：
Malakoutikhah, Morteza [1 ]
Teixido, Meritxell [1 ]
Giralt, Ernest [1 ,2 ]
机构：
[1] Inst Res Biomed IRB Barcelona, Barcelona 08028, Spain
[2] Univ Barcelona, Dept Organ Chem, Barcelona, Spain
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 35期
关键词：
blood-brain barrier; brain uptake; drug delivery; peptides; shuttle-mediated delivery; 80-COATED POLYBUTYLCYANOACRYLATE NANOPARTICLES; CENTRAL-NERVOUS-SYSTEM; CONJUGATED PEGYLATED NANOPARTICLES; BARRIER IN-VIVO; TARGETED DELIVERY; MONOCLONAL-ANTIBODY; ALZHEIMERS-DISEASE; FUSION PROTEIN; PHARMACOLOGICAL-ACTIVITY; TRANSFERRIN-RECEPTOR;
D O I：
10.1002/anie.201006565
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Advances in the field of shuttle-mediated drug delivery have been made in the last decade; however, the treatment of brain disorders still remains a great challenge because of the presence of the blood-brain barrier (BBB), a structure that limits the access of drugs to their site of action in the central nervous system. Several strategies have been proposed to enhance the transport of drugs across the BBB. In this Review, we focus on the vector-mediated approach, in which a drug is coupled to a molecule (shuttle) that has the ability to cross the BBB and deliver the drug to the brain. © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：7998 / 8014
页数：17
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