FIRST REPORT OF SARS-COV-2 DETECTION IN CEREBROSPINAL FLUID IN A CHILD WITH GUILLAIN-BARRE SYNDROME

被引：27

作者：

Araujo, Naiana Mota ^{[1
]}

Ferreira, Lis Campos ^{[2
,3
,5
]}

Dantas, Debora Paraiso ^{[3
]}

Silva, Denison Santos ^{[3
]}

dos Santos, Cliomar Alves ^{[4
]}

Cipolotti, Rosana ^{[5
]}

Martins-Filho, Paulo Ricardo ^{[5
,6
]}

机构：

[1] Fundacao Beneficencia Hosp Cirurgia, Med Residence Program, Aracaju, Brazil

[2] Univ Fed Sergipe, Neuroimmunol Clin, Sergipe, Brazil

[3] Univ Tiradentes, Dept Med, Aracaju, Brazil

[4] Sergipe State Hlth Secretariat, Hlth Fdn Parreiras Horta, Cent Lab Publ Hlth LACEN SE, Aracaju, Brazil

[5] Univ Fed Sergipe, Hlth Sci Grad Program, Sergipe, Brazil

[6] Univ Fed Sergipe, Invest Pathol Lab, Aracaju, Sergipe, Brazil

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2021年 / 40卷 / 07期

关键词：

COVID-19; SARS-CoV-2; Guillain-Barre syndrome; acute inflammatory polyradiculoneuropathy;

D O I：

10.1097/INF.0000000000003146

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Underlying mechanisms on the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and neurologic complications are still poorly understood. Cases of Guillain-Barre Syndrome (GBS) have been linked to the SARS-CoV-2 infection as the result of dysregulated immune response with damage in neuronal tissues. In the current report, we present the first pediatric case of GBS with detection of SARSCoV-2 in the cerebrospinal fluid (CFS). This unique case of COVID-19-associated GBS with detection of SARS-CoV-2 RNA in the CSF indicates direct viral involvement inducing peripheral nerve inflammation.

引用

页码：E274 / E276

页数：4

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