The molecular epidemiology of hepatitis E virus infection

被引：76

作者：

Purdy, Michael A. ^{[1
]}

Khudyakov, Yury E. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Natl Ctr HIV Hepatitis STD TB Prevent, Div Viral Hepatitis, Atlanta, GA 30333 USA

来源：

VIRUS RESEARCH | 2011年 / 161卷 / 01期

关键词：

Hepatitis E virus; Molecular epidemiology; Genotypes subtypes; Transmission; Population dynamics; GENOTYPE; 3; PHYLOGENETIC ANALYSIS; SPORADIC ACUTE; GENETIC IDENTIFICATION; NORTHERN INDIA; RISK-FACTORS; FOOD-BORNE; NON-A; TRANSMISSION; SWINE;

D O I：

10.1016/j.virusres.2011.04.030

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Molecular characterization of various hepatitis E virus (HEV) strains circulating among humans and animals (particularly swine, deer and boars) in different countries has revealed substantial genetic heterogeneity. The distinctive four-genotype distribution worldwide of mammalian HEV and varying degrees of genetic relatedness among local strains suggest a long and complex evolution of HEV in different geographic regions. The population expansion likely experienced by mammalian HEV in the second half of the 20th century is consistent with an extensive genetic divergence of HEV strains and high prevalence of HEV infections in many parts of the world, including developed countries. The rate and mechanisms of human-to-human transmission and zoonotic transmission to humans vary geographically, thus contributing to the complexity of HEV molecular evolution. Published by Elsevier B.V.

引用

页码：31 / 39

页数：9

共 128 条

[1] Experimental studies on subclinical hepatitis E virus infection in cynomolgus macaques [J].