Central nervous system inflammation

被引：13

作者：

Soriano, S. G. ^{[1
]}

Piva, S. ^{[2
]}

机构：

[1] Harvard Univ, Childrens Hosp, Sch Med, Boston, MA 02115 USA

[2] Univ Brescia, Dept Anesthesia, Brescia, Italy

来源：

EUROPEAN JOURNAL OF ANAESTHESIOLOGY | 2008年 / 25卷

关键词：

sepsis; inflammation; cytokines; central nervous system; cell adhesion molecules;

D O I：

10.1017/S0265021507003390

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Activation of inflammation is the hallmark of pathological processes that follow acute injury. This process is mediated by inflammatory cytokines and adhesion molecules that reside on the surface of endothelium, leucocyte and inflammatory cells. Attenuation of the adhesion cascade has been the subject of several basic science and clinical trials in the management of neurological injury. This review will highlight the role of adhesion molecules in the evolution of secondary injury after cerebral ischaemia and trauma. Potential therapeutic avenues will then be discussed.

引用

页码：154 / 159

页数：6

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