Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise

被引：23

作者：

Aydin, Sibel Z. ^{[1
]}

Direskeneli, Haner ^{[2
]}

Merkel, Peter A. ^{[3
,4
]}

机构：

[1] Univ Ottawa, Ottawa Hosp Res Inst, Div Rheumatol, Ottawa, ON, Canada

[2] Marmara Univ, Fac Med, Div Rheumatol, Istanbul, Turkey

[3] Univ Penn, Div Rheumatol, Philadelphia, PA 19104 USA

[4] Univ Penn, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA

来源：

JOURNAL OF RHEUMATOLOGY | 2017年 / 44卷 / 12期

关键词：

VASCULITIS; TAKAYASU ARTERITIS; GIANT CELL ARTERITIS; LARGE VESSEL; OUTCOMES; GIANT-CELL ARTERITIS; TAKAYASUS-ARTERITIS; FEATURES; TURKEY;

D O I：

10.3899/jrheum.161269

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To arrive at consensus for candidate outcomes for disease activity assessment in large-vessel vasculitis (LVV) in clinical trials. Methods. A Delphi survey including 99 items was circulated among international experts for 3 rounds. Results. Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging. Conclusion. This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes.

引用

页码：1928 / 1932

页数：5

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