Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise

被引:23
作者
Aydin, Sibel Z. [1 ]
Direskeneli, Haner [2 ]
Merkel, Peter A. [3 ,4 ]
机构
[1] Univ Ottawa, Ottawa Hosp Res Inst, Div Rheumatol, Ottawa, ON, Canada
[2] Marmara Univ, Fac Med, Div Rheumatol, Istanbul, Turkey
[3] Univ Penn, Div Rheumatol, Philadelphia, PA 19104 USA
[4] Univ Penn, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA
关键词
VASCULITIS; TAKAYASU ARTERITIS; GIANT CELL ARTERITIS; LARGE VESSEL; OUTCOMES; GIANT-CELL ARTERITIS; TAKAYASUS-ARTERITIS; FEATURES; TURKEY;
D O I
10.3899/jrheum.161269
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To arrive at consensus for candidate outcomes for disease activity assessment in large-vessel vasculitis (LVV) in clinical trials. Methods. A Delphi survey including 99 items was circulated among international experts for 3 rounds. Results. Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging. Conclusion. This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes.
引用
收藏
页码:1928 / 1932
页数:5
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