Biological and Chemical Diversity of Ascidian-Associated Microorganisms

被引：36
作者：
Chen, Lei [1 ]
Hu, Jin-Shuang [1 ]
Xu, Jia-Lei [1 ]
Shao, Chang-Lun [2 ]
Wang, Guang-Yu [1 ]
机构：
[1] Harbin Inst Technol, Sch Marine Sci & Technol, Dept Bioengn, Weihai 264209, Peoples R China
[2] Ocean Univ China, Sch Med & Pharm, Minist Educ China, Lab Marine Drugs, Qingdao 266003, Peoples R China
来源：
MARINE DRUGS | 2018年 / 16卷 / 10期
基金：
中国国家自然科学基金;
关键词：
alkaloids; ascidian; bioactivity; diversity; microorganism; polyketides; HALOCYNTHIAE SP NOV; NATURAL-PRODUCTS; MARINE ISOLATE; GENE-CLUSTER; CYANOBACTERIAL SYMBIONT; BACTERIAL BIOSYNTHESIS; SESBANIA-DRUMMONDII; MICROBIAL DIVERSITY; BACILLUS-PUMILUS; CYCLIC PEPTIDE;
D O I：
10.3390/md16100362
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Ascidians are a class of sessile filter-feeding invertebrates, that provide unique and fertile niches harboring various microorganisms, such as bacteria, actinobacteria, cyanobacteria and fungi. Over 1000 natural products, including alkaloids, cyclic peptides, and polyketides, have been isolated from them, which display diverse properties, such as antibacterial, antifungal, antitumor, and anti-inflammatory activities. Strikingly, direct evidence has confirmed that 8% of natural products from ascidians are actually produced by symbiotic microorganisms. In this review, we present 150 natural products from microorganisms associated with ascidians that have been reported up to 2017.
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页数：33
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