LINE-1 and inflammatory gene methylation levels are early biomarkers of metabolic changes: association with adiposity

被引：22

作者：

Cardoso Carraro, Julia Cristina ^{[1
]}

Luisa Mansego, Maria ^{[2
]}

Ignacio Milagro, Fermin ^{[2
]}

Chaves, Larissa Oliveira ^{[1
]}

Vidigal, Fernanda Carvalho ^{[3
]}

Bressan, Josefina ^{[1
]}

Alfredo Martinez, J. ^{[2
]}

机构：

[1] Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil

[2] Univ Navarra, Dept Nutr Food Sci & Physiol, Ctr Nutr Res, CIBERobn,Fisiopatol Obesidad & Nutr,Inst Hlth Car, Madrid, Spain

[3] Univ Fed Alfenas, Dept Nutr, Alfenas, MG, Brazil

来源：

BIOMARKERS | 2016年 / 21卷 / 07期

关键词：

Global DNA methylation; healthy eating index; IL-6; metabolic syndrome; SERPINE1; GLOBAL DNA METHYLATION; HIGH-FAT DIET; BLOOD MONONUCLEAR-CELLS; PERIPHERAL-BLOOD; INSULIN-RESISTANCE; REPEAT REGION; OBESITY; EPIGENETICS; CANCER; TISSUE;

D O I：

10.3109/1354750X.2016.1171904

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We analyzed whether global and inflammatory genes methylation can be early predictors of metabolic changes and their associations with the diet, in a cross-sectional study (n = 40). Higher global methylation was associated to adiposity, insulin resistance, and lower quality of the diet. Methylation of IL-6, SERPINE1 and CRP genes was related to adiposity traits and macronutrients intake. SERPINE1 hypermethylation was also related to some metabolic alterations. CRP methylation was a better predictor of insulin resistance than CRP plasma concentrations. Global and inflammatory gene promoter hypermethylation can be good early biomarkers of adiposity and metabolic changes and are associated to the quality of the diet.

引用

页码：625 / 632

页数：8

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