Squarate Cross-Linked Gelatin Hydrogels as Three-Dimensional Scaffolds for Biomedical Applications

被引：7

作者：

Stucchi, Simone ^{[1
,2
]}

Colombo, Danilo ^{[1
,3
]}

Guizzardi, Roberto ^{[1
,4
]}

D'Aloia, Alessia ^{[1
]}

Collini, Maddalena ^{[5
,6
]}

Bouzin, Margaux ^{[5
]}

Costa, Barbara ^{[1
]}

Ceriani, Michela ^{[1
]}

Natalello, Antonino ^{[1
]}

Pallavicini, Piersandro ^{[7
]}

Cipolla, Laura ^{[1
]}

机构：

[1] Univ Milano Bicocca, Dept Biotechnol & Biosci, I-20126 Milan, Italy

[2] Univ N Carolina, Chapel Hill, NC 27515 USA

[3] Politecn Milan, Dept Chem Mat & Chem Engn Giulio Natta, Via Mancinelli 7, I-20131 Milan, Italy

[4] Tecnoservizi Ambientali Srl, Romano Di Lombardia, Italy

[5] Univ Milano Bicocca, Dept Phys Giuseppe Occhialini, I-20126 Milan, Italy

[6] Univ Milano Bicocca, Nanomed Ctr, I-20126 Milan, Italy

[7] Univ Pavia, Dept Chem, I-27100 Pavia, Italy

来源：

LANGMUIR | 2021年 / 37卷 / 48期

关键词：

CELL; SPECTROSCOPY; DIFFUSION; MATRIX; ACID;

D O I：

10.1021/acs.langmuir.1c02080

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hydrogels are useful platforms as three-dimensional (3D) scaffolds for cell culture, drug-release systems, and regenerative medicine applications. Here, we propose a novel chemical cross-linking approach by the use of 3,4-diethoxy-3-cyclobutene-1,2-dione or diethyl squarate for the preparation of 5 and 10% w/v gelatin-based hydrogels. Hydrogels showed good swelling properties, and the 5% gelatin-based hydrogel proved suitable as a 3D cell culture scaffold for the chondrocyte cell line C28/I2. In addition, diffusion properties of different sized molecules inside the hydrogel were determined.

引用

页码：14050 / 14058

页数：9

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