Effects of Goose Collagen and Collagen Peptide on Osteoporosis

被引：15

作者：

Wang, Pingping ^{[1
]}

Jiang, Jinli ^{[1
]}

Pan, Daodong ^{[1
,2
]}

Sun, Yangying ^{[1
]}

Wu, Zhen ^{[1
]}

Cao, Jinxuan ^{[1
]}

Zeng, Xiaoqun ^{[1
]}

机构：

[1] Ningbo Univ, Key Lab Anim Prot Deep Proc Technol Zhejiang Prov, Ningbo, Zhejiang, Peoples R China

[2] Nanjing Normal Univ, Dept Food Sci & Nutr, Jinling Coll, Nanjing, Jiangsu, Peoples R China

来源：

INTERNATIONAL JOURNAL OF FOOD PROPERTIES | 2016年 / 19卷 / 10期

关键词：

Collagen; Collagen peptide; BMSCs; Osteogenic differentiation; PEPSIN-SOLUBILIZED COLLAGEN; OSTEOBLAST DIFFERENTIATION; SOLUBLE COLLAGEN; EXTRACTION; BONE; SKIN; SCALE; HEAD;

D O I：

10.1080/10942912.2015.1115414

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The effects of collagen and collagen peptide from goose bone on osteoporosis were studied. Fourier transform infrared spectrometry, ultraviolet spectrum, differential scanning calorimetry, and sodium dodecyl sulfate polyacrylamide gel electrophoresis identified the goose collagen as typical type I collagen. Results showed that osteopontin, bone morphogenetic protein 2, runt-related transcription factor 2, and type I collagen levels in bone marrow mesenchymal stem cells supernatant were dramatically higher in the experimental groups than in the control group (p < 0.05), and was highest in the experimental group composed of low molecular weight collagen peptide linked with calcium. Then the osterix, runt-related transcription factor 2, transforming growth factor-1, and bone morphogenetic protein 2 expression levels related to osteogenetic differentiation were detected by real-time fluorescent quantitative polymerase chain reaction. The findings showed that goose collagen and collagen peptide can improve the gene expression related to osteogenetic differentiation which reflected the level of bone marrow mesenchymal stem cells to osteoblasts.

引用

页码：2190 / 2201

页数：12