The Application of Induced Pluripotent Stem Cells in Cardiac Disease Modeling and Drug Testing

被引：21
作者：
Ye, Lingqun [1 ,2 ]
Ni, Xuan [1 ,2 ]
Zhao, Zhen-Ao [1 ,2 ,3 ,4 ]
Lei, Wei [1 ,2 ,3 ,4 ]
Hu, Shijun [1 ,2 ,3 ,4 ]
机构：
[1] Soochow Univ, Coll Med, Affiliated Hosp 1, Inst Cardiovasc Sci, Suzhou 215000, Peoples R China
[2] Soochow Univ, Coll Med, Affiliated Hosp 1, Dept Cardiovasc Surg, Suzhou 215000, Peoples R China
[3] Key Lab Stem Cells & Biomed Mat Jiangsu Prov, Suzhou 215000, Peoples R China
[4] Chinese Minist Sci & Technol, Suzhou 215000, Peoples R China
来源：
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2018年 / 11卷 / 05期
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
Induced pluripotent stem cells; Cardiovascular diseases; Disease modeling; Drug testing; LONG-QT SYNDROME; IPSC-DERIVED CARDIOMYOCYTES; HYPERTROPHIC CARDIOMYOPATHY; DILATED CARDIOMYOPATHY; TISSUE; PHENOTYPE; HEART; RECAPITULATE; GENERATION; MATURATION;
D O I：
10.1007/s12265-018-9811-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In recent decades, cardiovascular diseases have become the greatest health threat to human beings, and thus it is particularly important to explore the subtle underlying pathogenesis of cardiovascular diseases. Although many molecular pathways have been explored to be essential in the development of cardiovascular diseases, their clinical significances are still uncertain. With the emergence of induced pluripotent stem cells (iPSCs), a unique platform for cardiovascular diseases has been established to model cardiovascular diseases on specific genetic background in vitro. This review summarizes current progresses of iPSCs in cardiovascular disease modeling and drug testing. This review highlighted iPSC-based cardiovascular disease modeling and drug testing. The technical advances in iPSC-based researches and various clinically relevant applications are discussed. With further intensive research, iPSC technology will shape the future of clinical translational research in cardiovascular diseases.
引用
收藏
页码：366 / 374
页数：9
相关论文
共 58 条
  • [1] Microfluidic heart on a chip for higher throughput pharmacological studies
    Agarwal, Ashutosh
    Goss, Josue Adrian
    Cho, Alexander
    McCain, Megan Laura
    Parker, Kevin Kit
    [J]. LAB ON A CHIP, 2013, 13 (18) : 3599 - 3608
  • [2] Sex hormones affect outcome in arrhythmogenic right ventricular cardiomyopathy/dysplasia: from a stem cell derived cardiomyocyte-based model to clinical biomarkers of disease outcome
    Akdis, Deniz
    Saguner, Ardan M.
    Shah, Khooshbu
    Wei, Chuanyu
    Medeiros-Domingo, Argelia
    von Eckardstein, Arnold
    Luscher, Thomas F.
    Brunckhorst, Corinna
    Chen, H. S. Vincent
    Duru, Firat
    [J]. EUROPEAN HEART JOURNAL, 2017, 38 (19) : 1498 - 1508
  • [3] Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity
    Burridge, Paul W.
    Li, Yong Fuga
    Matsa, Elena
    Wu, Haodi
    Ong, Sang-Ging
    Sharma, Arun
    Holmstrom, Alexandra
    Chang, Alex C.
    Coronado, Michael J.
    Ebert, Antje D.
    Knowles, Joshua W.
    Telli, Melinda L.
    Witteles, Ronald M.
    Blau, Helen M.
    Bernstein, Daniel
    Altman, Russ B.
    Wu, Joseph C.
    [J]. NATURE MEDICINE, 2016, 22 (05) : 547 - 556
  • [4] Modeling of Arrhythmogenic Right Ventricular Cardiomyopathy With Human Induced Pluripotent Stem Cells
    Caspi, Oren
    Huber, Irit
    Gepstein, Amira
    Arbel, Gil
    Maizels, Leonid
    Boulos, Monther
    Gepstein, Lior
    [J]. CIRCULATION-CARDIOVASCULAR GENETICS, 2013, 6 (06) : 557 - 568
  • [5] High throughput measurement of Ca2+ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry
    Cerignoli, Fabio
    Charlot, David
    Whittaker, Ross
    Ingermanson, Randy
    Gehalot, Piyush
    Savchenko, Alex
    Gallacher, David J.
    Towart, Rob
    Price, Jeffrey H.
    McDonough, Patrick M.
    Mercola, Mark
    [J]. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2012, 66 (03) : 246 - 256
  • [6] Approaches to in vitro tissue regeneration with application for human disease modeling and drug development
    Ebrahimkhani, Mohammad R.
    Young, Carissa L.
    Lauffenburger, Douglas A.
    Griffith, Linda G.
    Borenstein, Jeffrey T.
    [J]. DRUG DISCOVERY TODAY, 2014, 19 (06) : 754 - 762
  • [7] Human engineered heart tissue as a model system for drug testing
    Eder, Alexandra
    Vollert, Ingra
    Hansen, Arne
    Eschenhagen, Thomas
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2016, 96 : 214 - 224
  • [8] Matrigel Mattress A Method for the Generation of Single Contracting Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
    Feaster, Tromondae K.
    Cadar, Adrian G.
    Wang, Lili
    Williams, Charles H.
    Chun, Young Wook
    Hempel, Jonathan E.
    Bloodworth, Nathaniel
    Merryman, W. David
    Lim, Chee Chew
    Wu, Joseph C.
    Knollmann, Bjoern C.
    Hong, Charles C.
    [J]. CIRCULATION RESEARCH, 2015, 117 (12) : 995 - +
  • [9] Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy
    Gramlich, Michael
    Pane, Luna Simona
    Zhou, Qifeng
    Chen, Zhifen
    Murgia, Marta
    Schoetterl, Sonja
    Goedel, Alexander
    Metzger, Katja
    Brade, Thomas
    Parrotta, Elvira
    Schaller, Martin
    Gerull, Brenda
    Thierfelder, Ludwig
    Aartsma-Rus, Annemieke
    Labeit, Siegfried
    Atherton, John J.
    McGaughran, Julie
    Harvey, Richard P.
    Sinnecker, Daniel
    Mann, Matthias
    Laugwitz, Karl-Ludwig
    Gawaz, Meinrad Paul
    Moretti, Alessandra
    [J]. EMBO MOLECULAR MEDICINE, 2015, 7 (05) : 562 - 576
  • [10] An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death
    Granata, Alessandra
    Serrano, Felipe
    Bernard, William George
    McNamara, Madeline
    Low, Lucinda
    Sastry, Priya
    Sinha, Sanjay
    [J]. NATURE GENETICS, 2017, 49 (01) : 97 - 109
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