Mechanistic insight into the singlet oxygen-triggered expansion of hypoxia-responsive polymeric micelles

被引：22
作者：
Wang, Lina
Huang, Xiaoli
Wang, Bingbing
Zhao, Jie
Guo, Xuliang
Wang, Zheng
Zhao, Yanjun [1 ]
机构：
[1] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin Key Lab Modern Drug Delivery & High Effic, Tianjin 300072, Peoples R China
来源：
BIOMATERIALS SCIENCE | 2018年 / 6卷 / 07期
关键词：
DRUG-DELIVERY; NANOPARTICLES; CANCER; SIRNA; NANOCARRIERS; PROTEINS; TUMORS;
D O I：
10.1039/c8bm00369f
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Nitroimidazole-bearing nanomedicine has been popular as a hypoxia-responsive platform for on-demand drug delivery. We report the singlet oxygen-responsive property of nitroimidazole-containing micelles and the corresponding reaction mechanism, which would pave the way for developing a dual hypoxia- and singlet oxygen-sensitive drug delivery nanoplatform based on a simple nitroimidazole moiety.
引用
收藏
页码：1712 / 1716
页数：5
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