Viral monitoring and successful treatment of a ganciclovir-resistant cytomegalovirus infection in a heart transplant recipient

被引：2

作者：

Garcia-Martinez, J. ^{[1
]}

Folgueira, L. ^{[1
]}

Delgado, R. ^{[1
]}

Hernando, S. ^{[1
]}

Prieto, C. ^{[1
]}

Aguado, J. M. ^{[2
]}

Otero, J. R. ^{[1
]}

机构：

[1] Hosp Univ 12 Octubre, Dept Microbiol, Madrid, Spain

[2] Hosp Univ 12 Octubre, Infect Dis Unit, Madrid, Spain

来源：

TRANSPLANT INFECTIOUS DISEASE | 2008年 / 10卷 / 02期

关键词：

ganciclovir; cytomegalovirus; heart transplant; foscarnet; UL97; phosphotransferase;

D O I：

10.1111/j.1399-3062.2007.00243.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We reported a ganciclovir (GCV)-resistant cytomegalovirus (CMV) infection in a heart transplant recipient. Genotypic and phenotypic susceptibility assays demonstrated an A594V mutation in the UL97 phosphotransferase gene and GCV IC50 > 96 mu M. Low GCV concentration exposure, immunosuppressive treatment, donor-positive/recipient-negative CMV serostatus, viral reactivations within antiviral prophylaxis or treatment, contributed to GCV-resistant strain selection.

引用

页码：123 / 128

页数：6

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