Siblings Presenting With Progressive Congenital Aleukemic Leukemia Cutis

Congenital leukemia is infrequent, occurring in < 1% of pediatric leukemia patients, and mainly of myeloid lineage. Twenty-five to 30% of congenital leukemia cases present with cutaneous leukemic infiltrates. Rarely, infants will have aleukemic leukemia cutis, presenting with leukemic skin lesions but without systemic symptoms or bone marrow involvement. Few cases of congenital aleukemic leukemia cutis have been reported in the literature. The course of disease is variable as cases of spontaneous resolution have been described. Here we present the first report of siblings with progressive congenital aleukemic leukemia cutis, both treated successfully with myeloid leukemia chemotherapy. Pediatr Blood Cancer 2011;57:338-340. (C) 2011 Wiley-Liss, Inc.