Quinazolin-4(3H)-ones: A Tangible Synthesis Protocol via an Oxidative Olefin Bond Cleavage Using Metal-Catalyst Free Conditions

被引：7

作者：

Sharif, Muhammad ^{[1
]}

机构：

[1] King Fand Univ Petr & Minerals, Dept Chem, Dhahran 31261, Saudi Arabia

来源：

APPLIED SCIENCES-BASEL | 2020年 / 10卷 / 08期

关键词：

catalysis; metal-free; catalyst-free; quinazolinone; styrene; o-Aminobenzamide; antioxidant; anticancer; ONE-POT SYNTHESIS; CARBONYLATIVE SYNTHESIS; O-AMINOBENZAMIDES; PRIMARY ALCOHOLS; BENZYL ALCOHOLS; QUINAZOLINONES; OZONOLYSIS; DERIVATIVES; CONVENIENT; BENZAMIDES;

D O I：

10.3390/app10082815

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and selective oxidative procedure for the synthesis of quinazolinones from readily available o-aminobenzamides and styrenes was developed. A number of potentially pharmacologically relevant quinazolinones were prepared using metal- and catalyst-free conditions. The synthesis procedure highlights the sustainable operation, low-priced, free from perilous materials, green solvent and environmental affability. The synthesized products were isolated in moderate to excellent yields.

引用

页数：11

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