Glycine betaine metabolism in the acetogenic bacterium Acetobacterium woodii

被引：27

作者：

Lechtenfeld, Mats ^{[1
]}

Heine, Julia ^{[1
]}

Sameith, Janin ^{[1
]}

Kremp, Florian ^{[1
]}

Mueller, Volker ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Inst Mol Biosci, Dept Mol Microbiol & Bioenerget, Max von Laue Str 9, D-60438 Frankfurt, Germany

来源：

ENVIRONMENTAL MICROBIOLOGY | 2018年 / 20卷 / 12期

基金：

欧洲研究理事会;

关键词：

METHANOLCOENZYME M METHYLTRANSFERASE; METHANOSARCINA-MAZEI GO1; ESCHERICHIA-COLI; BACILLUS-SUBTILIS; CORYNEBACTERIUM-GLUTAMICUM; COMPATIBLE SOLUTES; CORRINOID PROTEIN; TRANSPORT-SYSTEM; METHYL TRANSFER; CARRIER BETP;

D O I：

10.1111/1462-2920.14389

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The quarternary, trimethylated amine glycine betaine (GB) is widespread in nature but its fate under anoxic conditions remains elusive. It can be used by some acetogenic bacteria as carbon and energy source but the pathway of GB metabolism has not been elucidated. We have identified a gene cluster involved in GB metabolism and studied acetogenesis from GB in the model acetogen Acetobacterium woodii. GB is taken up by a secondary active, Na+ coupled transporter of the betaine-choline-carnitine (BCC) family. GB is demethylated to dimethylglycine, the end product of the reaction, by a methyltransferase system. Further conversion of the methyl group requires CO2 as well as Na+ indicating that GB metabolism involves the Wood-Ljungdahl pathway. These studies culminate in a model for the path of carbon and electrons during acetogenensis from GB and a model for the bioenergetics of acetogenesis from GB.

引用

页码：4512 / 4525

页数：14

共 77 条

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