The functionalization of a cascade of C(sp2)-H/C(sp3)-H bonds: synthesis of fused dihydropyrazoles via visible-light photoredox catalysis

被引：38
|
作者：
Cheng, Jian [1 ]
Xu, Pan [1 ]
Li, Weipeng [1 ]
Cheng, Yixiang [1 ]
Zhu, Chengjian [1 ,2 ]
机构：
[1] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Nanjing 210023, Jiangsu, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 80期
基金：
中国国家自然科学基金;
关键词：
PHOTOCATALYTIC GENERATION; DUAL CATALYSIS; STRATEGY; DIFLUOROALKYLATION; CYCLIZATION; DISCOVERY; ARYLATION; RADICALS; AMINES;
D O I：
10.1039/c6cc06410h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The functionalization of a cascade of C(sp(2))-H/C(sp(3))-H bonds in aldehyde hydrazones with simple 2,2-dibromo-1,3-dicarbonyls was achieved via visible-light photoredox catalysis. This method, which involves free radical addition, polar crossover and 6 pi electrocyclic reaction, provides an efficient approach for the synthesis of complex fused dihydropyrazoles and related derivatives with moderate to good yields and excellent regioselectivity under mild reaction conditions.
引用
收藏
页码：11901 / 11904
页数：4
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