The symphony of the ninth: the development and function of Th9 cells

被引：75

作者：

Jabeen, Rukhsana ^{[1
]}

Kaplan, Mark H. ^{[1
,2
]}

机构：

[1] Herman B Wells Ctr Pediat Res, Dept Pediat, Indianapolis, IN 46202 USA

[2] Indiana Univ Sch Med, Dept Microbiol & Immunol, Indianapolis, IN 46202 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2012年 / 24卷 / 03期

关键词：

T-CELLS; TGF-BETA; IL-9; EXPRESSION; AIRWAY INFLAMMATION; DIFFERENTIATION; PU.1; INDUCTION; GROWTH; GATA-3; LEADS;

D O I：

10.1016/j.coi.2012.02.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD4+ T helper cells are obligate regulators of inflammatory disease. An expanding cadre of T helper (Th) subsets, specialized for promoting particular types of inflammation, function through the secretion of a restricted set of cytokines. The latest addition to the list of subsets is the Th9 cell that secretes IL-9 as a signature cytokine and contributes to several classes of inflammatory disease. In this review we focus on recent advances in understanding the development of Th9 cells, and how Th9 cells contribute to the orchestration of disease.

引用

页码：303 / 307

页数：5

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