A mitochondria-targeted nitric oxide donor triggered by superoxide radical to alleviate myocardial ischemia/reperfusion injury

被引：16
|
作者：
Hou, Jingli [1 ]
He, Haiyan [2 ]
Huang, Saipeng [3 ]
Qian, Meng [1 ]
Wang, Jie [2 ]
Tan, Xiaoli [1 ]
Han, Guifang [1 ]
Song, Yuguang [1 ]
Xu, Zhelong [2 ]
Liu, Yangping [1 ]
机构：
[1] Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China
[2] Tianjin Med Univ, Dept Physiol & Pathophysiol, Tianjin 300070, Peoples R China
[3] Northwest Univ, Sch Chem Engn, Xian, Shaanxi, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 09期
基金：
中国国家自然科学基金;
关键词：
REPERFUSION INJURY; L-ARGININE; ISCHEMIA; INFARCTION; MODULATION; CHEMISTRY; THERAPY; RELEASE; PROBE;
D O I：
10.1039/c8cc07304j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel mitochondria-targeted superoxide-responsive nitric oxide donor was developed by incorporation of diphenylphosphinyl and triphenylphosphonium groups into diazeniumdiolate,enabling remarkable protection against ischemia/reperfusion injury in H9c2 cells and isolated rat hearts.
引用
收藏
页码：1205 / 1208
页数：4
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