The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox)

被引：438

作者：

Szakacs, Gergely ^{[1
,2
]}

Varadi, Andras ^{[2
]}

Oezvegy-Laczka, Csilla ^{[1
]}

Sarkadi, Balazs ^{[1
]}

机构：

[1] Hungarian Acad Sci, Natl Med Ctr, Inst Haematol & Immunol, Membrane Res Grp, H-1113 Budapest, Hungary

[2] Hungarian Acad Sci, Inst Enzymol, H-1113 Budapest, Hungary

来源：

DRUG DISCOVERY TODAY | 2008年 / 13卷 / 9-10期

关键词：

D O I：

10.1016/j.drudis.2007.12.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

ATP binding cassette (ABC) drug transporters play an important role in cancer drug resistance, protection against xenobiotics, and in general in the passage of drugs through cellular and tissue barriers. This review explores how human ABC transporters modulate the pharmacological effects of various drugs, and how this predictable ADME-TOX modulation can be used during the process of drug discovery and development. We provide a description of the relevant human ABC drug transporters and review the models and assay systems that can be applied for the analysis of their expected drug interactions. The use of the in vitro, in vivo, in silico models, their combination, and the emerging clinical information are evaluated with respect to their potential application in early drug screening.

引用

页码：379 / 393

页数：15

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