Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL)

被引:16
作者
O'Hayre, M. [1 ,2 ]
Niederst, M. [2 ,3 ]
Fecteau, J. F. [4 ]
Nguyen, V. M. [3 ]
Kipps, T. J. [4 ]
Messmer, D. [4 ]
Newton, A. C. [3 ]
Handel, T. M. [1 ]
机构
[1] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Biomed Sci Grad Program, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
[4] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
关键词
PROTEIN-KINASE-C; B-CELLS; ACTIVATION; APOPTOSIS; AKT;
D O I
10.1038/leu.2012.6
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:1689 / 1692
页数:5
相关论文
共 14 条
  • [1] Burger JA, 2000, BLOOD, V96, P2655
  • [2] Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression
    Chen, Muhan
    Pratt, Christopher P.
    Zeeman, Martha E.
    Schultz, Nikolaus
    Taylor, Barry S.
    O'Neill, Audrey
    Castillo-Martin, Mireia
    Nowak, Dawid G.
    Naguib, Adam
    Grace, Danielle M.
    Murn, Jernej
    Navin, Nick
    Atwal, Gurinder S.
    Sander, Chris
    Gerald, William L.
    Cordon-Cardo, Carlos
    Newton, Alexandra C.
    Carver, Brett S.
    Trotman, Lloyd C.
    [J]. CANCER CELL, 2011, 20 (02) : 173 - 186
  • [3] Valproate induces replication-independent active DNA demethylation
    Detich, N
    Bovenzi, V
    Szyf, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (30) : 27586 - 27592
  • [4] The phosphatase PHLPP controls the cellular levels of protein kinase C
    Gao, Tianyan
    Brognard, John
    Newton, Alexandra C.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (10) : 6300 - 6311
  • [5] PHLPP: A phosphatase that directly dephosphorylates akt, promotes apoptosis, and suppresses tumor growth
    Gao, TY
    Furnari, F
    Newton, AC
    [J]. MOLECULAR CELL, 2005, 18 (01) : 13 - 24
  • [6] The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling
    Hussain, S.
    Foreman, O.
    Perkins, S. L.
    Witzig, T. E.
    Miles, R. R.
    van Deursen, J.
    Galardy, P. J.
    [J]. LEUKEMIA, 2010, 24 (09) : 1641 - 1655
  • [7] Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis
    Liu, J.
    Weiss, H. L.
    Rychahou, P.
    Jackson, L. N.
    Evers, B. M.
    Gao, T.
    [J]. ONCOGENE, 2009, 28 (07) : 994 - 1004
  • [8] Cancer DNA Methylation: Molecular Mechanisms and Clinical Implications
    McCabe, Michael T.
    Brandes, Johann C.
    Vertino, Paula M.
    [J]. CLINICAL CANCER RESEARCH, 2009, 15 (12) : 3927 - 3937
  • [9] Chronic lymphocytic leukemia cells receive RAF-dependent survival signals in response to CXCL12 that are sensitive to inhibition by sorafenib
    Messmer, Davorka
    Fecteau, Jessie-F.
    O'Hayre, Morgan
    Bharati, Ila S.
    Handel, Tracy M.
    Kipps, Thomas J.
    [J]. BLOOD, 2011, 117 (03) : 882 - 889
  • [10] Metastatic potential of 21T human breast cancer cells depends on Akt/protein kinase B activation
    Qiao, Meng
    Iglehart, J. Dirk
    Pardee, Arthur B.
    [J]. CANCER RESEARCH, 2007, 67 (11) : 5293 - 5299