Facial nerve palsy after acute exposure to dichloromethane

被引:6
作者
Jacubovich, RM [1 ]
Landau, D [1 ]
Bar Dayan, Y [1 ]
Zilberberg, M [1 ]
Goldstein, L [1 ]
机构
[1] IDF Home Front Command, Or Yehuda, Israel
关键词
dichloromethane; methylene chloride; facial nerve palsy; paint stripping; paint remover; toxicity; ventilation; occupational exposure;
D O I
10.1002/ajim.20215
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background Dichloromethane poisoning affects predominantly the central nervous and the cardiovascular systems, and results from. both carboxyhemoglobin formation and direct solvent-related narcosis. Exposure is frequently occupational and related to paint stripping. Several reports have described severe adverse effects as well as fatalities. Conflicting reports regarding peripheral nerve toxicity have been found with no reports of clinical acute toxicity heretofore. Methods We present a case report of a patient who developed a facial nerve palsy after acute occupational exposure to Dichloromethane. The patient was part of a paint removing crew who have worked without proper protecting measures and were thus exposed to high levels of Dichoromethane. Results The patient was involved in paint stripping with Dichloromethane, and developed facial nerve palsy. Other known causes of facial palsy were excluded, and although idiopathic palsy cannot be ruled out, there were no corroborating findings. Carboxyhemoglobin levels taken after a significant delay were normal. Conclusion This is the first article that describes a case of Facial Nerve Palsy related to acute dichloromethane exposure, indicating a possible peripheral neurotoxic effect of this solvent.
引用
收藏
页码:389 / 392
页数:4
相关论文
共 26 条
[1]  
Agency for Toxic Substances and Disease Registry (ATSDR), 1998, TOX PROF METH CHLOR
[2]  
[Anonymous], 1994, OCCUPATIONAL MED
[3]  
BAKINSON MA, 1985, BRIT J IND MED, V42, P184
[4]  
CHERRY N, 1981, BRIT J IND MED, V38, P351
[5]   UPTAKE, METABOLISM, AND ELIMINATION OF METHYLENE-CHLORIDE VAPOR BY HUMANS [J].
DIVINCENZO, GD ;
KAPLAN, CJ .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1981, 59 (01) :130-140
[6]  
FELDMAN RG, 1968, NEUROLOGY, V18, P309
[7]   Fatal case of dichloromethane poisoning [J].
Goullé, JP ;
Lacroix, C ;
Vaz, E ;
Rouvier, P ;
Proust, B .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1999, 23 (05) :380-383
[8]   METHYLENE-CHLORIDE EXPOSURE IN FURNITURE-STRIPPING SHOPS - VENTILATION AND RESPIRATOR USE PRACTICES [J].
HALL, AH ;
RUMACK, BH .
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 1990, 32 (01) :33-37
[9]  
Hayes W.J., 1991, Handbook of Pesticide Toxicology
[10]  
*IPCS, 1997, METH CHLOR TOX