Usefulness of serum neopterin levels in acute decompensated heart failure to predict renal dysfunction

Context: Neopterin serum concentration increases in the presence of renal dysfunction. Objective: We sought to determine the relationship between admission serum neopterin levels and worsening renal function (WRF) in patients with heart failure (HF). Methods: We prospectively measured serum neopterin levels in patients with HF and the patients were subdivided into two groups: with and without WRF during hospital admission. Results: Logistic regression analysis showed that high serum neopterin levels at admission were associated with a greater likelihood of developing WRF. Conclusions: Patients admitted to hospital with HF, elevated serum neopterin levels are associated with an increased risk of developing WRF.