Synthesis of Water-Soluble Phosphine Oxides by Pd/C-Catalyzed P-C Coupling in Water

被引：79

作者：

Rummelt, Stephan M. ^{[1
,2
]}

Ranocchiari, Marco ^{[1
]}

van Bokhoven, Jeroen A. ^{[1
,2
]}

机构：

[1] Paul Scherrer Inst, Dept Synchrotron Radiat & Nanotechnol, CH-5232 Villigen, Switzerland

[2] ETH, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 08期

关键词：

PHOSPHORUS-CARBON BOND; SECONDARY PHOSPHINES; ARYL PHOSPHINES; PALLADIUM; LIGANDS; TRIPHENYLPHOSPHINE; TRIARYLPHOSPHINES; COMPLEXES; HALIDES; THIOLS;

D O I：

10.1021/ol300582y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cross-coupling between diphenylphosphine oxide and halogenated benzoic acids catalyzed by Pd/C in water is a green, simple, and fast protocol to obtain water-soluble tertiary phosphine oxides without the addition of ligands and additives. Low reaction times and microwave irradiation make this method general and excellent for laboratory and large-scale synthesis without the need to use organic solvents in reactions and workup.

引用

页码：2188 / 2190

页数：3

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