Protein-like Nanoparticles Based on Orthogonal Self-Assembly of Chimeric Peptides

被引：8

作者：

Jiang, Linhai ^{[1
]}

Xu, Dawei ^{[1
]}

Namitz, Kevin E. ^{[2
]}

Cosgrove, Michael S. ^{[2
]}

Lund, Reidar ^{[3
]}

Dong, He ^{[1
]}

机构：

[1] Clarkson Univ, Dept Chem & Biomol Sci, 8 Clarkson Ave, Potsdam, NY 13699 USA

[2] SUNY Upstate Med Univ, Dept Biochem & Mol Biol, 766 Irving Ave, Syracuse, NY 13210 USA

[3] Univ Oslo, Dept Chem, N-0315 Oslo, Norway

来源：

SMALL | 2016年 / 12卷 / 37期

关键词：

nanoparticles; peptides; protein folding; self-assembly; COLLAGEN-MIMETIC PEPTIDES; COILED COILS; COMPUTATIONAL DESIGN; TRIPLE HELICES; NANOMATERIALS; STABILITY; OLIGOMERS; SYMMETRY; CAGES;

D O I：

10.1002/smll.201600910

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel two-component self-assembling chimeric peptide is designed where two orthogonal protein folding motifs are linked side by side with precisely defined position relative to one another. The self-assembly is driven by a combination of symmetry controlled molecular packing, intermolecular interactions, and geometric constraint to limit the assembly into compact dodecameric protein nanoparticles. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5126 / 5131

页数：6

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