Protein-like Nanoparticles Based on Orthogonal Self-Assembly of Chimeric Peptides

被引：8
|
作者：
Jiang, Linhai [1 ]
Xu, Dawei [1 ]
Namitz, Kevin E. [2 ]
Cosgrove, Michael S. [2 ]
Lund, Reidar [3 ]
Dong, He [1 ]
机构：
[1] Clarkson Univ, Dept Chem & Biomol Sci, 8 Clarkson Ave, Potsdam, NY 13699 USA
[2] SUNY Upstate Med Univ, Dept Biochem & Mol Biol, 766 Irving Ave, Syracuse, NY 13210 USA
[3] Univ Oslo, Dept Chem, N-0315 Oslo, Norway
来源：
SMALL | 2016年 / 12卷 / 37期
关键词：
nanoparticles; peptides; protein folding; self-assembly; COLLAGEN-MIMETIC PEPTIDES; COILED COILS; COMPUTATIONAL DESIGN; TRIPLE HELICES; NANOMATERIALS; STABILITY; OLIGOMERS; SYMMETRY; CAGES;
D O I：
10.1002/smll.201600910
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel two-component self-assembling chimeric peptide is designed where two orthogonal protein folding motifs are linked side by side with precisely defined position relative to one another. The self-assembly is driven by a combination of symmetry controlled molecular packing, intermolecular interactions, and geometric constraint to limit the assembly into compact dodecameric protein nanoparticles. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：5126 / 5131
页数：6
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