The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice

被引：13

作者：

Chen, Lijuan ^{[1
]}

Yan, Xin ^{[2
]}

Yan, Qianlin ^{[1
]}

Fan, Jiajun ^{[3
]}

Huang, Hai ^{[3
]}

Shi, Xunlong ^{[3
]}

Han, Lei ^{[3
]}

Han, Tianxiong ^{[1
]}

Zhu, Haiyan ^{[3
]}

机构：

[1] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Chinese Med, Shanghai 200092, Peoples R China

[2] Tongji Univ, Sch Med, Inst Chinese Med, Shanghai 200092, Peoples R China

[3] Fudan Univ, Sch Pharm, Dept Biosynth, Shanghai 201203, Peoples R China

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2015年 / 2015卷

基金：

中国国家自然科学基金;

关键词：

TOLL-LIKE RECEPTORS; A VIRUS; DEPENDENT ACTIVATION; CYTOKINE; CELLS; INFECTION; INNATE; RECOGNITION; INFLAMMATION; PROPAGATION;

D O I：

10.1155/2015/790739

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

A new approach to treat infections of highly pathogenic influenza virus is to inhibit excessive innate immune response. JiuWei QiangHuo decoction has been used for centuries for the treatment of pulmonary disorders in China. In this study, we evaluated the anti-inflammatory activities of the modified JiuWei QiangHuo (MJWQH) decoction in the treatment of influenza A (H1N1) virus-induced severe pneumonia in mice. The results showed that MJWQH significantly increased the survival rate of H1N1-infected mice and suppressed the production of TNF-alpha, IL-1, IL-6, MCP-1, RANTES, and IFN-alpha on day 4 after infection. Moreover, oral administration of MJWQH efficiently inhibited virus replication and alleviated the severity of lung injuries. The results also showed that MJWQH may have potential therapeutic effect on severe lung injury induced by H1N1 virus by regulating the NF-kappa B pathway. Our study suggested that MJWQH might be an alternative therapy for the treatment of viral pneumonia.

引用

页数：12

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