MEDI 53-Synthesis and biologic evaluation of selective inhibitors of 11β-HSD1 as a potential treatment for metabolic disorders

被引：0
|
作者：
Neelamkavil, Santhosh F. [1 ]
Boyle, Craig D. [1 ]
Chackalamannil, Samuel [1 ]
Baker, Hana [1 ]
Kowalski, Timothy [1 ]
Zhang, Lili [1 ]
Terracina, Giuseppe [1 ]
机构：
[1] Schering Plough Res Inst, CV Metab Dis Res, Kenilworth, NJ 07033 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 234卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
53-MEDI
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Inhibitors of 11β-HSD1: A Potential Treatment for the Metabolic Syndrome
    Jean, David J. St., Jr.
    Wang, Minghan
    Fotsch, Christopher
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2008, 8 (17) : 1508 - 1523
  • [2] Evaluation of selective inhibitors of 11β-HSD1 for the treatment of hypertension
    Bauman, David R.
    Whitehead, Alan
    Contino, Lisa C.
    Cui, Jisong
    Garcia-Calvo, Margarita
    Gu, Xin
    Kevin, Nancy
    Ma, Xiuying
    Pai, Lee-yuh
    Shah, Kashmira
    Shen, Xiaolan
    Stribling, Sloan
    Zokian, Hratch J.
    Metzger, Joe
    Shevell, Diane E.
    Waddell, Sherman T.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (12) : 3650 - 3653
  • [3] Discovery of potent and selective inhibitors of 11β-HSD1 for the treatment of metabolic syndrome
    Richards, Steven
    Sorensen, Bryan
    Jae, Hwan-Soo
    Winn, Marty
    Chen, Yixian
    Wang, Jiahong
    Fung, Steven
    Monzon, Katina
    Frevert, Ernst U.
    Jacobson, Peer
    Sham, Hing
    Link, J. T.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (24) : 6241 - 6245
  • [4] Synthesis of selective 11β-HSD1 inhibitors based on dammarane scaffold
    Shao, Li-Dong
    Bao, Ying
    Shen, Yu
    Su, Jia
    Leng, Ying
    Zhao, Qin-Shi
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 135 : 324 - 338
  • [5] MEDI 49-Novel analogs as 11β-HSD1 inhibitors
    Shah, Unmesh
    Boyle, Craig D.
    Chackalamannil, Samuel
    Baker, Hana
    Kowalski, Timothy
    Zhang, Lili
    Terracina, Giuseppe
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 234
  • [6] A highly efficient synthesis of potent and selective butyrolactam inhibitors of 11β-Hsd1
    Yeh, Vince S. C.
    Kurukulasuriya, Ravi
    Kerdesky, Francis A.
    ORGANIC LETTERS, 2006, 8 (18) : 3963 - 3966
  • [7] Synthesis and biological evaluation of heterocycle containing adamantane 11β-HSD1 inhibitors
    Yeh, Vince S. C.
    Patel, Jyoti R.
    Yong, Hong
    Kurukulasuriya, Ravi
    Fung, Steven
    Monzon, Katina
    Chiou, William
    Wang, Jiahong
    Stolarik, Deanne
    Imade, Hovis
    Beno, David
    Brune, Michael
    Jacobson, Peer
    Sham, Hing
    Link, J. T.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (20) : 5414 - 5419
  • [8] Discovery of pyridyl sulfonamide 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors for the treatment of metabolic disorders
    Yoon, David S.
    Wu, Shung C.
    Seethala, Ramakrishna
    Golla, Rajasree
    Nayeem, Akbar
    Everlof, John G.
    Gordon, David A.
    Hamann, Lawrence G.
    Robl, Jeffrey A.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (21) : 5045 - 5049
  • [9] The synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors
    Yan, Xuelei
    Wang, Zhulun
    Sudom, Athena
    Cardozo, Mario
    DeGraffenreid, Michael
    Di, Yongmei
    Fan, Pingchen
    He, Xiao
    Jaen, Juan C.
    Labelle, Marc
    Liu, Jinsong
    Ma, Ji
    McMinn, Dustin
    Miao, Shichang
    Sun, Daqing
    Tang, Liang
    Tu, Hua
    Ursu, Stefania
    Walker, Nigel
    Ye, Qiuping
    Powers, Jay P.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (23) : 7071 - 7075
  • [10] Synthesis and biological evaluation of sulfonamidooxazoles as selective inhibitors of the 11B-HSD1, a potential treatment for diabetes
    Xiang, JS
    Manus, I
    Massefski, W
    Suri, V
    Tam, M
    Xin, YZ
    Tobin, J
    Xu, X
    McKew, J
    Tam, S
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U146 - U146
12345