Accuracy of different oxygenation indices in estimating intrapulmonary shunting at increasing infusion rates of dobutamine in horses under general anaesthesia

被引：29

作者：

Briganti, A. ^{[1
]}

Portela, D. A. ^{[1
]}

Grasso, S. ^{[2
]}

Sgorbini, M. ^{[1
]}

Tayari, H. ^{[1
]}

Bassini, J. R. Fusar ^{[1
]}

Vitale, V. ^{[1
]}

Romano, M. S. ^{[3
]}

Crovace, A. ^{[4
]}

Breghi, G. ^{[1
]}

Staffieri, F. ^{[4
]}

机构：

[1] Univ Pisa, Dipartimento Sci Vet, Pisa, Italy

[2] Univ Bari, DETO Sez Anestesia & Terapia Intens, Bari, Italy

[3] Univ Florence, AOUC Careggi, Internal Med & Cardiol, Dept Expt & Clin Med, Florence, Italy

[4] Univ Bari, DETO Sez Clin Vet & Prod Anim, Bari, Italy

来源：

VETERINARY JOURNAL | 2015年 / 204卷 / 03期

关键词：

Anaesthesia; F-shunt; Horse; Intrapulmonary shunt; Oxygenation index; CRITICALLY-ILL PATIENTS; ANESTHETIZED HORSES; CARDIAC-OUTPUT; VENOUS ADMIXTURE; AGREEMENT; VARIABLES; DELIVERY; FAILURE; TENSION;

D O I：

10.1016/j.tvjl.2015.04.002

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The aim of this study was to evaluate the correlation of commonly used oxygenation indices with venous admixture (Qs/Qt) in anaesthetised horses under different infusion rates of dobutamine. Six female horses were anaesthetised with acepromazine, xylazine, diazepam, ketamine, and isoflurane, and then intubated and mechanically ventilated with 100% O-2. A Swan-Ganz catheter was introduced into the left jugular vein and its tip advanced into the pulmonary artery. Horses received different standardised rates of dobutamine. For each horse, eight samples of arterial and mixed venous blood were simultaneously obtained at fixed times. Arterial and venous haemoglobin (Hb) concentration and 02 saturation, arterial oxygen partial pressure (PaO2), venous oxygen partial pressure (PvO(2)), and barometric pressure were measured. Arterial (CaO2), mixed venous (CvO(2)), and capillary (Cc'O-2) oxygen contents were calculated using standard formulae. The correlations between F-shunt, arterial oxygen tension to fraction of inspired oxygen ratio (PaO2/FiO(2)), arterial to alveolar oxygen tension ratio (PaO2/PAO(2)), alveolar to arterial oxygen tension difference (P[A - a]O-2), and respiratory index (P[A - a]O-2/PaO2) were tested with linear regression analysis. The goodness-of-fit for each calculated formula was evaluated by means of the coefficient of determination (r(2)). The agreement between Qs/Qt and F-shunt was analysed with the Bland-Altman test. All tested oxygen tension-based indices were weakly correlated (r(2)<0.2) with the Qs/Qt, whereas F-shunt showed a stronger correlation (r(2) = 0.73). F-shunt also showed substantial agreement with Qs/Qt independent of the dobutamine infusion rate. F-shunt better correlated with Qs/Qt than other oxygen indices in isoflurane-anaesthetised horses under different infusion rates of dobutamine. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：351 / 356

页数：6

共 27 条

[1] Use of the oxygen content-based index, Fshunt, as an indicator of pulmonary venous admixture at various inspired oxygen fractions in anesthetized sheep [J].