Decellularized extracellular matrix: New promising and challenging biomaterials for regenerative medicine

被引：150

作者：

Brown, Mika ^{[1
]}

Li, Jianyu ^{[1
,2
]}

Moraes, Christopher ^{[1
,3
]}

Tabrizian, Maryam ^{[1
,4
,5
,10
]}

Li-Jessen, Nicole Y. K. ^{[1
,6
,7
,8
,9
]}

机构：

[1] McGill Univ, Dept Biomed Engn, Montreal, PQ, Canada

[2] McGill Univ, Dept Mech Engn, Montreal, PQ, Canada

[3] McGill Univ, Dept Chem Engn, Montreal, PQ, Canada

[4] McGill Univ, Dept Bioengn, Montreal, PQ, Canada

[5] McGill Univ, Fac Dent, Montreal, PQ, Canada

[6] McGill Univ, Sch Commun Sci & Disorders, Montreal, PQ, Canada

[7] McGill Univ, Dept Otolaryngol Head & Neck Surg, Montreal, PQ, Canada

[8] McGill Univ, Res Inst, Hlth Ctr, Montreal, PQ, Canada

[9] 2001 McGill Coll Ave,8th Floor, Montreal, PQ H3A 1G1, Canada

[10] Duff Med Bldg,3775 Univ St,Room 313, Montreal, PQ H3A 2B4, Canada

来源：

BIOMATERIALS | 2022年 / 289卷

基金：

美国国家卫生研究院;

关键词：

Tissue engineering; Decellularized extracellular matrix; Injectable hydrogels; Electrospun scaffolds; Bioprinted scaffolds; MESENCHYMAL STEM-CELLS; ADIPOSE-TISSUE MICROCARRIERS; FACTOR-RELEASING HYDROGELS; SMALL-INTESTINE SUBMUCOSA; MECHANICAL-PROPERTIES; ECM HYDROGEL; IN-VITRO; INJECTABLE HYDROGEL; ARTICULAR-CARTILAGE; FIBROBLAST ACTIVATION;

D O I：

10.1016/j.biomaterials.2022.121786

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Extracellular matrix is rich in biomolecules including structural proteins, glycosaminoglycans, and small mole-cules that are important for the maintenance and repair of tissue. Decellularized extracellular matrix (dECM) is expected to retain these key biomolecules and makes it a promising biomaterial candidate for regenerative medicine applications. To date, dECM-particle based biomaterials have been developed to engineer over 15 tissue types or organs, with the ultimate goal of mimicking specific biological and physical properties of the native tissue. The most common scaffold types are injectable hydrogels, electrospun scaffolds and bioprinted scaffolds. The purpose of this review paper is to highlight key challenges, fabrication methods and progress made for each tissue type, along with the discussion of other elements that are integral to push dECM biomaterials towards effective and specialized tissue repair.

引用

页数：60

共 411 条

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