Coronary Arterial Function and Disease in Women With No Obstructive Coronary Arteries

被引：40
作者：
Reynolds, Harmony R. [2 ]
Merz, C. Noel Bairey [1 ]
Berry, Colin [3 ,4 ,5 ]
Samuel, Rohit [6 ]
Saw, Jacqueline [6 ]
Smilowitz, Nathaniel R. [2 ]
de Souza, Ana Carolina do A. H. [7 ,8 ,9 ]
Sykes, Robert [4 ]
Taqueti, Viviany R. [7 ,8 ,9 ]
Wei, Janet [1 ]
机构：
[1] Cedars Sinai Med Ctr, Smidt Heart Inst, Barbra Streisand Womens Heart Ctr, 127 S San Vicente Blvd A3212, Los Angeles, CA 90048 USA
[2] New York Univ Grossman Sch Med, Sarah Ross Soter Ctr Womens Cardiovasc Res, Dept Med, Leon H Charney Div Cardiol, New York, NY USA
[3] Univ Glasgow, British Heart Fdn Glasgow Cardiovasc Res Ctr, Glasgow, Lanark, Scotland
[4] Golden Jubilee Natl Hosp, West Scotland Heart & Lung Ctr, Glasgow, Lanark, Scotland
[5] Queen Elizabeth Univ Hosp, NHS Greater Glasgow & Clyde Hlth Board, Dept Cardiol, Glasgow, Lanark, Scotland
[6] Univ British Columbia, Vancouver Gen Hosp, Vancouver, BC, Canada
[7] Harvard Med Sch, Dept Radiol, Cardiovasc Imaging Program, Boston, MA 02115 USA
[8] Harvard Med Sch, Dept Med Cardiol, Cardiovasc Imaging Program, Boston, MA 02115 USA
[9] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA
来源：
CIRCULATION RESEARCH | 2022年 / 130卷 / 04期
基金：
英国医学研究理事会;
关键词：
coronary disease; coronary vessels; myocardial infarction; risk factors; sex characteristics; ACUTE MYOCARDIAL-INFARCTION; ISCHEMIC-HEART-DISEASE; SEX-RELATED DIFFERENCES; LONG-TERM PROGNOSIS; COMPUTED-TOMOGRAPHY ANGIOGRAPHY; POSITRON-EMISSION-TOMOGRAPHY; BYPASS GRAFT-SURGERY; MICROVASCULAR DYSFUNCTION; FLOW RESERVE; GENDER-DIFFERENCES;
D O I：
10.1161/CIRCRESAHA.121.319892
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Ischemic heart disease (IHD) is the leading cause of mortality in women. While traditional cardiovascular risk factors play an important role in the development of IHD in women, women may experience sex-specific IHD risk factors and pathophysiology, and thus female-specific risk stratification is needed for IHD prevention, diagnosis, and treatment. Emerging data from the past 2 decades have significantly improved the understanding of IHD in women, including mechanisms of ischemia with no obstructive coronary arteries and myocardial infarction with no obstructive coronary arteries. Despite this progress, sex differences in IHD outcomes persist, particularly in young women. This review highlights the contemporary understanding of coronary arterial function and disease in women with no obstructive coronary arteries, including coronary anatomy and physiology, mechanisms of ischemia with no obstructive coronary arteries and myocardial infarction with no obstructive coronary arteries, noninvasive and invasive diagnostic strategies, and management of IHD.
引用
收藏
页码：529 / 551
页数：23
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