Interleukin-12 suppresses immunoglobulin E production but enhances immunoglobulin G4 production by human peripheral blood mononuclear cells

被引：33

作者：

deBoer, BA ^{[1
]}

Kruize, YCM ^{[1
]}

Rotmans, PJ ^{[1
]}

Yazdanbakhsh, M ^{[1
]}

机构：

[1] LEIDEN UNIV,DEPT PARASITOL,FAC MED,NL-2300 RC LEIDEN,NETHERLANDS

来源：

INFECTION AND IMMUNITY | 1997年 / 65卷 / 03期

关键词：

D O I：

10.1128/IAI.65.3.1122-1125.1997

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of interleukin-12 (IL-12) on human immunoglobulin G4 (IgG4) and IgE production was examined with cells derived from filarial patients and European controls. IL-12 inhibited IgE release but enhanced IgG4 production in cultures of peripheral blood mononuclear cells stimulated with anti-CD2 plus IL-2. When purified T- and B-cell cocultures were examined, IL-12 again markedly enhanced IgG4, whereas IgE production was no longer inhibited.

引用

页码：1122 / 1125

页数：4

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