Effects of Lutein Supplementation on Macular Pigment Optical Density and Visual Acuity in Patients with Age-Related Macular Degeneration

被引:118
|
作者
Weigert, Guenther [2 ]
Kaya, Semira [1 ]
Pemp, Berthold [1 ,2 ]
Sacu, Stefan [2 ]
Lasta, Michael [1 ]
Werkmeister, Rene Marcel [3 ]
Dragostinoff, Nikolaus [3 ]
Simader, Christian [2 ]
Garhofer, Gerhard [1 ]
Schmidt-Erfurth, Ursula [2 ]
Schmetterer, Leopold [1 ,3 ]
机构
[1] Med Univ Vienna, Dept Clin Pharmacol, A-1090 Vienna, Austria
[2] Med Univ Vienna, Dept Ophthalmol, A-1090 Vienna, Austria
[3] Med Univ Vienna, Ctr Med Phys & Biomed Engn, A-1090 Vienna, Austria
关键词
EYE DISEASE; VITAMIN-C; MACULOPATHY; CAROTENOIDS; ZEAXANTHIN; EPIDEMIOLOGY; POPULATION; ANCILLARY; PROGRESS; TRIAL;
D O I
10.1167/iovs.11-7522
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
PURPOSE. There is evidence from several large-scale clinical trials that reduced intake of lutein, a major component of the macular pigment, is a risk factor for the development of AMD. In the present study (LISA; Lutein Intervention Study Austria) it was hypothesized that lutein supplementation increases macular pigment optical density (MPOD). In addition, an investigation was conducted into whether lutein supplementation improves visual acuity (VA) and macular function (mean differential light threshold; MDLT), as assessed with microperimetry. METHODS. One hundred twenty-six patients with AMD (AREDS [Age-related Eye Disease Study] stages 2, 3, and 4) were included in this randomized (2: 1), placebo-controlled, double-masked parallel group study. Lutein or placebo was administered for 6 months. MPOD was measured with a custom-built reflectometer. VA was assessed with ETDRS (Early Treatment Diabetic Retinopathy Study) charts, and MDLT was assessed with a microperimeter. RESULTS. Lutein significantly increased MPOD by 27.9% +/- 2.9% (P = 0.001 versus placebo). No significant effect of lutein supplementation on MDLT or VA was seen, although a tendency toward an increase was seen for both parameters (MDLT, P = 0.096 versus placebo; VA, P = 0.070 versus placebo). A significant correlation was found, however, between the increase in MPOD after 6 months and the increase in MDLT after 6 months (r = 0.25, P = 0.027), as well as between the increase in MPOD after 6 months and the increase in VA after 6 months (r = 0.27, P = 0.013). CONCLUSIONS. The present study demonstrates that lutein supplementation increases MPOD, as assessed with an objective method. The correlation between the change in MPOD and the change in VA and MDLT indicates that patients who show a pronounced increase in MPOD also benefit in terms of visual function. (ClinicalTrials.gov number, NCT00879671.) (Invest Ophthalmol Vis Sci. 2011; 52: 8174-8178) DOI:10.1167/iovs.11-7522
引用
收藏
页码:8174 / 8178
页数:5
相关论文
共 50 条
  • [31] Assessment of macular pigment optical density (MPOD) in patients with unilateral wet age-related macular degeneration (AMD)
    Gupta, Aditi
    Raman, Rajiv
    Biswas, Sayantan
    ACTA OPHTHALMOLOGICA, 2012, 90 (03) : e235 - e235
  • [32] Assessment of macular pigment optical density in patients with unilateral wet age-related macular degeneration: authors reply
    Tsika, Chrysanthi
    Tsilimbaris, Miltiadis K.
    Makridaki, Maria
    Kontadakis, Georgios
    Plainis, Sotiris
    Moschandreas, Joanna
    ACTA OPHTHALMOLOGICA, 2012, 90 (03) : e236 - e236
  • [33] Visual acuity and fixation characteristics in age-related, macular degeneration
    Cacho, Isabel
    Dickinson, Christine M.
    Reeves, Barnaby C.
    Harper, Robert A.
    OPTOMETRY AND VISION SCIENCE, 2007, 84 (06) : 487 - 495
  • [34] Visual Acuity after Cataract Surgery in Patients with Age-Related Macular Degeneration
    Nancy Huynh
    Nicholson, Benjamin P.
    Agron, Elvira
    Clemons, Traci E.
    Bressler, Susan B.
    Rosenfeld, Philip J.
    Chew, Emily Y.
    OPHTHALMOLOGY, 2014, 121 (06) : 1229 - 1236
  • [35] Visual acuity after cataract surgery in patients with age-related macular degeneration
    Baatz, H.
    Darawsha, R.
    Scharioth, G.
    De Ortueta, D.
    Ackermann, H.
    OPHTHALMOLOGE, 2008, 105 (10): : 927 - 930
  • [36] Macular Morphology and Visual Acuity in the Comparison of Age-related Macular Degeneration Treatments Trials
    Jaffe, Glenn J.
    Martin, Daniel F.
    Toth, Cynthia A.
    Daniel, Ebenezer
    Maguire, Maureen G.
    Ying, Gui-Shuang
    Grunwald, Juan E.
    Huang, Jiayan
    OPHTHALMOLOGY, 2013, 120 (09) : 1860 - 1870
  • [37] The effects of aflibercept following bevacizumab or ranibizumab on visual acuity and central macular thickness in patients with age-related macular degeneration
    Faridi, Ambar
    Shippey, Loton
    Hwang, Thomas
    Lauer, Andreas
    Bailey, Steven
    Flaxel, Christina
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2013, 54 (15)
  • [38] Influence of drusenoid pigment epithelial detachments on the progression of age-related macular degeneration and visual acuity
    Hollaus, Marlene
    Iby, Johannes
    Brugger, Jonas
    Leingang, Oliver
    Reiter, Gregor S.
    Schmidt-Erfurth, Ursula
    Sacu, Stefan
    CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE, 2024, 59 (06): : 417 - 423
  • [39] Macular pigment density variation after supplementation of lutein and zeaxanthin using the Visucam(R) 200 pigment module: Impact of age-related macular degeneration and lens status
    Azar, G.
    Maftouhi, M. Quaranta-El
    Masella, J-J.
    Mauget-Faysse, M.
    JOURNAL FRANCAIS D OPHTALMOLOGIE, 2017, 40 (04): : 303 - 313
  • [40] Macular zeaxanthins and lutein - a review of dietary sources and bioavailability and some relationships with macular pigment optical density and age-related macular disease
    Thurnham, David I.
    NUTRITION RESEARCH REVIEWS, 2007, 20 (02) : 163 - 179