The role of long non-coding RNAs in chromatin structure and gene regulation: variations on a theme

被引：56
作者：
Umlauf, David [1 ]
Fraser, Peter [1 ]
Nagano, Takashi [1 ]
机构：
[1] Babraham Inst, Lab Chromatin & Gene Express, Cambridge CB22 3AT, England
来源：
BIOLOGICAL CHEMISTRY | 2008年 / 389卷 / 04期
基金：
英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词：
histone modifications; nuclear organization; transcription; transcription factories;
D O I：
10.1515/BC.2008.047
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transcriptome studies have uncovered a plethora of non-coding RNAs (ncRNA) in mammals. Most originate within intergenic regions of the genome and recent evidence indicates that some are involved in many different pathways that ultimately act on genome architecture and gene expression. In this review, we discuss the role of well-characterized long ncRNAs in gene regulation pointing to their similarities, but also their differences. We will attempt to highlight a paradoxical situation in which transcription is needed to repress entire chromosomal domains possibly through the action of ncRNAs that create nuclear environments refractory to transcription.
引用
收藏
页码：323 / 331
页数：9
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