Effects of cryotherapy on high-dose melphalan-induced oral mucositis in pediatric patients undergoing autologous stem cell transplantation

被引：4
|
作者：
Kawaguchi, Koji [1 ]
Umeda, Katsutsugu [2 ]
Takachi, Takayuki [1 ]
Ogura, Taemi [1 ]
Horikoshi, Yasuo [1 ]
Saida, Satoshi [2 ]
Kato, Itaru [2 ]
Hiramatsu, Hidefumi [2 ]
Adachi, Souichi [3 ]
Takita, Junko [2 ]
Watanabe, Kenichiro [1 ]
机构：
[1] Shizuoka Childrens Hosp, Dept Hematol & Oncol, Shizuoka, Japan
[2] Kyoto Univ, Grad Sch Med, Dept Pediat, Kyoto, Japan
[3] Kyoto Univ, Grad Sch Med, Dept Human Hlth Sci, Kyoto, Japan
来源：
PEDIATRIC BLOOD & CANCER | 2020年 / 67卷 / 09期
关键词：
autologous stem cell transplantation; children; cryotherapy; melphalan; oral mucositis; TOTAL-BODY IRRADIATION; CONDITIONING REGIMENS; INDUCED STOMATITIS; MULTIPLE-MYELOMA; PREVENTION; CHILDREN; CHEMOTHERAPY; CANCER;
D O I：
10.1002/pbc.28495
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cryotherapy is a conventional method for preventing melphalan-induced oral mucositis (OM) in adult patients. We retrospectively examined the clinical benefits of cryotherapy in 41 pediatric patients undergoing autologous stem cell transplantation using a melphalan-etoposide-carboplatin regimen. Twenty-two patients received cryotherapy. The cumulative incidence of grade 3-4 OM was significantly lower in the cryotherapy group (57.1%) than in the noncryotherapy group (89.5%;P = .041). Multivariate analyses identified cryotherapy and the melphalan dose as independent factors for the lower occurrence of OM. The present study demonstrates the clinically significant efficacy of cryotherapy for preventing melphalan-induced OM in pediatric patients.
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页数：4
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