Bi 456906, structural properties and pharmacology of the novel glucagon and glucagon-like peptide-1 receptor (GCGR/GLP-1R) dual agonist

被引：0
作者：
Augustin, R. [1 ]
Zimmermann, T. [1 ]
Thomas, L. [1 ]
Baader-Pagler, T. [1 ]
Haebel, P. [1 ]
Simon, E. [1 ]
Klein, H. [1 ]
Santhanam, R. [1 ]
Reindl, W. [1 ]
Bajrami, B. [1 ]
Rist, W. [1 ]
Uphues, I. [1 ]
Hamprecht, D. [2 ]
Neubauer, H. [1 ]
机构：
[1] Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany
[2] Pharmaxis Ltd, Frenchs Forest, NSW, Australia
来源：
DIABETOLOGIA | 2022年 / 65卷 / SUPPL 1期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
570
引用
收藏
页码：S292 / S292
页数：1
相关论文
共 50 条
  • [21] Treatment of Type 1 Diabetic Patients with Glucagon-Like Peptide-1 (GLP-1) and GLP-1R Agonists
    Kielgast, Urd
    Holst, Jens J.
    Madsbad, Sten
    CURRENT DIABETES REVIEWS, 2009, 5 (04) : 266 - 275
  • [22] Glucagon-like peptide-1 receptor
    Krashes, Michael
    CURRENT BIOLOGY, 2024, 34 (23) : R1163 - R1164
  • [23] Clinical pharmacology of glucagon-like peptide-1 receptor agonists
    Sfairopoulos, Dimitrios
    Liatis, Stavros
    Tigas, Stelios
    Liberopoulos, Evangelos
    HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM, 2018, 17 (03): : 333 - 350
  • [24] Development of in vivo imaging agents targeting glucagon-like peptide-1 receptor (GLP-1R) in pancreatic islets
    Kimura, Hiroyuki
    Ogawa, Yu
    Kawashima, Hidekazu
    Mukai, Eri
    Toyoda, Kentaro
    Fujimoto, Hiroyuki
    Hirao, Konomu
    Ono, Masahiro
    Inagaki, Nobuya
    Saji, Hideo
    JOURNAL OF NUCLEAR MEDICINE, 2009, 50
  • [25] Clinical pharmacology of glucagon-like peptide-1 receptor agonists
    Dimitrios Sfairopoulos
    Stavros Liatis
    Stelios Tigas
    Evangelos Liberopoulos
    Hormones, 2018, 17 : 333 - 350
  • [26] Glucagon and glucagon-like peptide-1
    Livingston, JN
    Schoen, WR
    ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 34, 1999, 34 : 189 - 198
  • [27] Efficacy, Safety, and Mechanistic Insights of Cotadutide, a Dual Receptor Glucagon-Like Peptide-1 and Glucagon Agonist
    Parker, Victoria E. R.
    Robertson, Darren
    Wang, Tao
    Hornigold, David C.
    Petrone, Marcella
    Cooper, Aidan T.
    Posch, Maximilian G.
    Heise, Tim
    Plum-Moerschel, Leona
    Schlichthaar, Heike
    Klaus, Beate
    Ambery, Philip D.
    Meier, Juris J.
    Hirshberg, Boaz
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2020, 105 (03) : 803 - 820
  • [28] Structural and functional study of human full-length glucagon-like peptide 1 receptor GLP-1R
    Fan, W.
    Stevens, R. C.
    JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 2018, 50 (06) : 598 - 598
  • [29] Computational insight into conformational states of glucagon-like peptide-1 receptor (GLP-1R) and its binding mode with GLP-1
    Zhang, Juan
    Gu, Shikai
    Sun, Xianqiang
    Li, Weihua
    Tang, Yun
    Liu, Guixia
    RSC ADVANCES, 2016, 6 (16): : 13490 - 13497
  • [30] Glucagon-like peptide-1 receptor (GLP1-R) mRNA in the rat hypothalamus
    Shughrue, PJ
    Lane, MV
    Merchenthaler, I
    ENDOCRINOLOGY, 1996, 137 (11) : 5159 - 5162
12345