Embryonic Heterogeneity of Smooth Muscle Cells in the Complex Mechanisms of Thoracic Aortic Aneurysms

被引：6

作者：

Ito, Sohei ^{[1
,2
]}

Lu, Hong S. ^{[1
,2
,3
]}

Daugherty, Alan ^{[1
,2
,3
]}

Sawada, Hisashi ^{[1
,2
,3
]}

机构：

[1] Univ Kentucky, Coll Med, Saha Cardiovasc Res Ctr, Lexington, KY 40536 USA

[2] Univ Kentucky, Coll Med, Saha Aort Ctr, Lexington, KY 40536 USA

[3] Univ Kentucky, Coll Med, Dept Physiol, Lexington, KY 40536 USA

来源：

GENES | 2022年 / 13卷 / 09期

基金：

美国国家卫生研究院;

关键词：

aorta; aneurysm; cardiac neural crest; second heart field; smooth muscle; thoracic aorta; EHLERS-DANLOS-SYNDROME; CARDIAC NEURAL CREST; 2ND HEART FIELD; MARFAN-SYNDROME; ASCENDING AORTA; MUTATIONS; ARTERIAL; PATHOGENESIS; DISSECTIONS; DISEASE;

D O I：

10.3390/genes13091618

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Smooth muscle cells (SMCs) are the major cell type of the aortic wall and play a pivotal role in the pathophysiology of thoracic aortic aneurysms (TAAs). TAAs occur in a region-specific manner with the proximal region being a common location. In this region, SMCs are derived embryonically from either the cardiac neural crest or the second heart field. These cells of distinct origins reside in specific locations and exhibit different biological behaviors in the complex mechanism of TAAs. The purpose of this review is to enhance understanding of the embryonic heterogeneity of SMCs in the proximal thoracic aorta and their functions in TAAs.

引用

页数：10

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