Effect of Polylysine on Scrapie Prion Protein Propagation in Spleen during Asymptomatic Stage of Experimental Prion Disease in Mice

被引：3

作者：

Titlow, William B. ^{[1
,7
]}

Waqas, Muhammad ^{[2
]}

Lee, Jihyun ^{[2
]}

Cho, Jae Youl ^{[3
]}

Lee, Sang Yeol ^{[4
]}

Kim, Dae-Hwan ^{[5
]}

Ryou, Chongsuk ^{[1
,2
,5
,6
]}

机构：

[1] Univ Kentucky, Coll Med, Sander Brown Ctr Aging, Lexington, KY 40536 USA

[2] Hanyang Univ, Coll Pharm, Dept Pharm, Ansan 15588, South Korea

[3] Sungkyunkwan Univ, Dept Genet Engn, Suwon 16419, South Korea

[4] Gachon Univ, Dept Life Sci, Songnam 13120, South Korea

[5] Hanyang Univ, Inst Pharmaceut Technol, Ansan 15588, South Korea

[6] Univ Kentucky, Coll Med, Dept Microbiol Immunol & Mol Genet, Lexington, KY 40536 USA

[7] Univ Kentucky, Coll Med, Dept Physiol, Lexington, KY 40536 USA

来源：

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 2016年 / 26卷 / 09期

关键词：

Prion; PrPSc; animal model; spleen; brain; polylysine;

D O I：

10.4014/jmb.1601.01057

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Prion diseases are incurable neurodegenerative disorders. Our previous study demonstrated that polylysine was effective in prolonging the incubation period in a rodent model and in alleviating the scrapie prion protein (PrPSc) burden in the brain at the terminal stage of the disease. Here, we report that intraperitoneal administration of polylysine suppresses the accumulation of prions in the spleen during the early stages of the disease. This study supports the congruence of PrPSc inhibition by polylysine in both the spleen and brain.

引用

页码：1657 / 1660

页数：4

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