Current and Future Management of Malignant Mesothelioma: A Consensus Report from the National Cancer Institute Thoracic Malignancy Steering Committee, International Association for the Study of Lung Cancer, and Mesothelioma Applied Research Foundation

被引：90

作者：

Tsao, Anne S. ^{[1
]}

Lindwasser, O. Wolf ^{[2
]}

Adjei, Alex A. ^{[3
]}

Adusumilli, Prasad S. ^{[4
]}

Beyers, Matthew L. ^{[5
]}

Blumenthal, Gideon M. ^{[6
]}

Bueno, Raphael ^{[7
]}

Burt, Bryan M. ^{[8
]}

Carbone, Michele ^{[9
]}

Dahlberg, Suzanne E. ^{[10
]}

de Perrot, Marc ^{[11
,12
]}

Fennell, Dean A. ^{[13
,14
]}

Friedberg, Joseph ^{[15
]}

Gill, Ritu R. ^{[16
]}

Gomez, Daniel R. ^{[17
]}

Harpole, David H., Jr. ^{[18
]}

Hassan, Raffit ^{[19
]}

Hesdorffer, Mary ^{[20
]}

Hirsch, Fred R. ^{[21
]}

Hmeljak, Julija ^{[22
]}

Kindler, Hedy L. ^{[23
]}

Korn, Edward L. ^{[24
]}

Liu, Geoffrey ^{[25
]}

Mansfield, Aaron S. ^{[3
]}

Nowak, Anna K. ^{[26
,27
]}

Pass, Harvey I. ^{[28
]}

Peikert, Tobias ^{[29
]}

Rimner, Andreas ^{[30
]}

Robinson, Bruce W. S. ^{[31
,32
]}

Rosenzweig, Kenneth E. ^{[33
]}

Rusch, Valerie W. ^{[4
]}

Salgia, Ravi ^{[34
]}

Sepesi, Boris ^{[35
]}

Simone, Charles B., II ^{[36
]}

Sridhara, Rajeshwari ^{[5
]}

Szlosarek, Peter ^{[37
]}

Taioli, Emanuela ^{[38
,39
]}

Tsao, Ming-Sound ^{[40
,41
]}

Yang, Haining ^{[8
]}

Zauderer, Marjorie G. ^{[42
]}

Malik, Shakun M. ^{[43
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA

[2] NCI, Coordinating Ctr Clin Trials, NIH, Bethesda, MD 20892 USA

[3] Mayo Clin, Div Med Oncol, Rochester, MN USA

[4] Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave, New York, NY 10021 USA

[5] Emmes Corp, Rockville, MD USA

[6] US FDA, Silver Spring, MD USA

[7] Brigham & Womens Hosp, Thorac Surg, 75 Francis St, Boston, MA 02115 USA

[8] Baylor Coll Med, Dept Surg, Div Thorac Surg, Houston, TX 77030 USA

[9] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA

[10] Dana Farber Canc Inst, Dept Biostat, Boston, MA 02115 USA

[11] Toronto Gen Hosp, Div Thorac Surg, Toronto, ON, Canada

[12] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada

[13] Univ Leicester, Dept Genet & Genome Biol, Leicester, Leics, England

[14] Univ Hosp Leicester, Leicester, Leics, England

[15] Univ Maryland, Ctr Canc, Dept Thorac Surg, Baltimore, MD 21201 USA

[16] Brigham & Womens Hosp, Dept Radiol, 75 Francis St, Boston, MA 02115 USA

[17] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA

[18] Duke Univ, Dept Surg, Div Cardiothorac Surg, Durham, NC USA

[19] NCI, Thorac & GI Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[20] Mesothelioma Appl Res Fdn, Alexandria, VA USA

[21] Univ Colorado, Ctr Canc, IASLC, Denver, CO 80262 USA

[22] Co Biologists, Cambridge, England

[23] Univ Chicago, Dept Med, Hematol Oncol Sect, Chicago, IL 60637 USA

[24] NCI, Biometr Res Program, NIH, Bethesda, MD 20892 USA

[25] Princess Margaret Canc Ctr, Toronto, ON, Canada

[26] Univ Western Australia, Sch Med, Perth, WA, Australia

[27] Univ Western Australia, Natl Ctr Asbestos Related Dis, Perth, WA, Australia

[28] NYU, Dept Cardiothorac Surg, Langone Med Ctr, New York, NY USA

[29] Mayo Clin, Div Pulm & Crit Care Med, Rochester, MN USA

[30] Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, 1275 York Ave, New York, NY 10021 USA

[31] Univ Western Australia, Natl Ctr Asbestos Related Dis, Nedlands, WA, Australia

[32] Sir Charles Gairdner Hosp, Dept Resp Med, Nedlands, WA, Australia

[33] Mt Sinai Med Ctr, Dept Radiat Oncol, New York, NY 10029 USA

[34] City Hope Natl Med Ctr, Dept Med Oncol & Therapeut Res, Duarte, CA USA

[35] Univ Texas MD Anderson Canc Ctr, Dept Thorac & Cardiovasc Surg, Houston, TX 77030 USA

[36] Univ Maryland, Med Ctr, Dept Radiat Oncol, Baltimore, MD 21201 USA

[37] Queen Mary Univ London, Barts Canc Inst, London, England

[38] Icahn Sch Med Mt Sinai, Epidemiol, New York, NY 10029 USA

[39] Icahn Sch Med Mt Sinai, Dept Thorac Surg, New York, NY 10029 USA

[40] Univ Toronto, Dept Pathol, Toronto, ON, Canada

[41] Univ Toronto, Dept Pathol, Princess Margaret Canc Ctr, Univ Hlth Network, Toronto, ON, Canada

[42] Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA

[43] NCI, Clin Invest Branch, Canc Therapy Evaluat Program, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF THORACIC ONCOLOGY | 2018年 / 13卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Malignant mesothelioma; Pleural; Clinical trials; Multimodality therapy; Targeted therapy; PHASE-II TRIAL; PEGYLATED ARGININE DEIMINASE; PLEURAL MESOTHELIOMA; EXTRAPLEURAL PNEUMONECTOMY; HEMITHORACIC RADIATION; SPONTANEOUS REGRESSION; MULTIMODALITY THERAPY; RECIST CRITERIA; DOUBLE-BLIND; SURVIVAL;

D O I：

10.1016/j.jtho.2018.08.2036

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

On March 28- 29, 2017, the National Cancer Institute (NCI) Thoracic Malignacy Steering Committee, International Association for the Study of Lung Cancer, and Mesothelioma Applied Research Foundation convened the NCI-International Association for the Study of Lung Cancer-Mesothelioma Applied Research Foundation Mesothelioma Clinical Trials Planning Meeting in Bethesda, Maryland. The goal of the meeting was to bring together lead academicians, clinicians, scientists, and the U.S. Food and Drug Administration to focus on the development of clinical trials for patients in whom malignant pleural mesothelioma has been diagnosed. In light of the discovery of new cancer targets affecting the clinical development of novel agents and immunotherapies in malignant mesothelioma, the objective of this meeting was to assemble a consensus on at least two or three practice-changing multimodality clinical trials to be conducted through NCI's National Clinical Trials Network. Crown Copyright (C) 2018 Published by Elsevier Inc.

引用

页码：1655 / 1667

页数：13

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