The phosphatase Cdc14 triggers mitotic exit by reversal of CDK-dependent phosphorylation

被引：643
作者：
Visintin, R
Craig, K
Hwang, ES
Prinz, S
Tyers, M
Amon, A
机构：
[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
[2] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Programme Canc & Mol Biol, Toronto, ON M5G 1X5, Canada
来源：
MOLECULAR CELL | 1998年 / 2卷 / 06期
关键词：
D O I：
10.1016/S1097-2765(00)80286-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Exit from mitosis requires the inactivation of mitotic cyclin-dependent kinases (CDKs) by an unknown mechanism. We show that the Gdc14 phosphatase triggers mitotic exit: by three parallel mechanisms, each of which inhibits Cdk activity. Cdc14 dephosphorylates Sic1,a Cdk inhibitor, and Swi5, a transcription factor for SIC1, and induces degradation of mitotic cyclins, likely by dephosphorylating the activator of mitotic cyclin degradation, Cdh1/Hct1. Feedback between these pathways may lead to precipitous collapse of mitotic CDK activity and help coordinate exit from mitosis.
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收藏
页码：709 / 718
页数：10
相关论文
共 63 条
[1]   Swi5 controls a novel wave of cyclin synthesis in late mitosis [J].
Aerne, BL ;
Johnson, AL ;
Toyn, JH ;
Johnston, LH .
MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (04) :945-956
[2]   Regulation of B-type cyclin proteolysis by Cdc28-associated kinases in budding yeast [J].
Amon, A .
EMBO JOURNAL, 1997, 16 (10) :2693-2702
[3]   MECHANISMS THAT HELP THE YEAST-CELL CYCLE CLOCK TICK - G2 CYCLINS TRANSCRIPTIONALLY ACTIVATE G2 CYCLINS AND REPRESS G1 CYCLINS [J].
AMON, A ;
TYERS, M ;
FUTCHER, B ;
NASMYTH, K .
CELL, 1993, 74 (06) :993-1007
[4]   CLOSING THE CELL-CYCLE CIRCLE IN YEAST - G2 CYCLIN PROTEOLYSIS INITIATED AT MITOSIS PERSISTS UNTIL THE ACTIVATION OF G1 CYCLINS IN THE NEXT CYCLE [J].
AMON, A ;
IRNIGER, S ;
NASMYTH, K .
CELL, 1994, 77 (07) :1037-1050
[5]   A SUPPRESSOR OF A HIS4 TRANSCRIPTIONAL DEFECT ENCODES A PROTEIN WITH HOMOLOGY TO THE CATALYTIC SUBUNIT OF PROTEIN PHOSPHATASES [J].
ARNDT, KT ;
STYLES, CA ;
FINK, GR .
CELL, 1989, 56 (04) :527-537
[6]   SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box [J].
Bai, C ;
Sen, P ;
Hofmann, K ;
Ma, L ;
Goebl, M ;
Harper, JW ;
Elledge, SJ .
CELL, 1996, 86 (02) :263-274
[7]   The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae [J].
Charles, JF ;
Jespersen, SL ;
Tinker-Kulberg, RL ;
Hwang, L ;
Szidon, A ;
Morgan, DO .
CURRENT BIOLOGY, 1998, 8 (09) :497-507
[8]  
CHIANG CM, 1993, PEPTIDE RES, V6, P62
[9]   Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p [J].
CohenFix, O ;
Peters, JM ;
Kirschner, MW ;
Koshland, D .
GENES & DEVELOPMENT, 1996, 10 (24) :3081-3093
[10]   P40(SDB25), A PUTATIVE CDK INHIBITOR, HAS A ROLE IN THE M/G(1) TRANSITION IN SACCHAROMYCES-CEREVISIAE [J].
DONOVAN, JD ;
TOYN, JH ;
JOHNSON, AL ;
JOHNSTON, LH .
GENES & DEVELOPMENT, 1994, 8 (14) :1640-1653
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